TY - JOUR
T1 - Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146
AU - Ouhtit, Allal
AU - Gaur, Rajiv L.
AU - Abd Elmageed, Zakaria Y.
AU - Fernando, Augusta
AU - Thouta, Rajesh
AU - Trappey, Alison K.
AU - Abdraboh, Mohamed E.
AU - El-Sayyad, Hassan I.
AU - Rao, Prakash
AU - Raj, Madhwa G.H.
N1 - Funding Information:
Dr. Ouhtit is supported by the Louisiana Cancer Research Consortium and the LSU Health Sciences Translational grants.
PY - 2009/4
Y1 - 2009/4
N2 - CD146, also known as melanoma cell adhesion molecule or MCAM, is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis. CD146 promotes tumor progression of many cancers including melanoma and prostate. Strikingly, its expression is frequently lost in breast carcinoma cells, and it may act as a suppressor of breast cancer progression. While upstream mechanisms regulating CD146 are well documented, our understanding of the downstream molecular events underlying its mode of action remains to be elucidated. This review aims to focus on the progress in understanding the signaling mechanisms and the functional relevance of CD146, a multifaceted molecule, in cancer with particular emphasis on its role in inhibiting breast cancer progression.
AB - CD146, also known as melanoma cell adhesion molecule or MCAM, is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis. CD146 promotes tumor progression of many cancers including melanoma and prostate. Strikingly, its expression is frequently lost in breast carcinoma cells, and it may act as a suppressor of breast cancer progression. While upstream mechanisms regulating CD146 are well documented, our understanding of the downstream molecular events underlying its mode of action remains to be elucidated. This review aims to focus on the progress in understanding the signaling mechanisms and the functional relevance of CD146, a multifaceted molecule, in cancer with particular emphasis on its role in inhibiting breast cancer progression.
KW - Angiogenesis
KW - Breast cancer
KW - CD146
KW - Signal transduction
KW - Tumor suppressor
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U2 - 10.1016/j.bbcan.2009.01.002
DO - 10.1016/j.bbcan.2009.01.002
M3 - Review article
C2 - 19356677
AN - SCOPUS:62749184254
SN - 0304-419X
VL - 1795
SP - 130
EP - 136
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 2
ER -
