The potential role of miRNAs in the pathogenesis of schizophrenia – A focus on signaling pathways interplay

Mohamed Bakr Zaki; Ahmed I. Abulsoud; Alaa Ashraf; Nourhan M. Abdelmaksoud; Al Aliaa M. Sallam; Shaza H. Aly; Fatma Sa'eed El-Tokhy; Ahmed A. Rashad; Walaa A. El-Dakroury; Sherif S. Abdel Mageed; Yousra Nomier; Mahmoud A. Elrebehy; Shereen Saeid Elshaer; Mohammed S. Elballal; Osama A. Mohammed; Mustafa Ahmed Abdel-Reheim; Ahmed S. Doghish

doi:10.1016/j.prp.2024.155102

The potential role of miRNAs in the pathogenesis of schizophrenia – A focus on signaling pathways interplay

Mohamed Bakr Zaki, Ahmed I. Abulsoud, Alaa Ashraf, Nourhan M. Abdelmaksoud, Al Aliaa M. Sallam, Shaza H. Aly, Fatma Sa'eed El-Tokhy, Ahmed A. Rashad, Walaa A. El-Dakroury, Sherif S. Abdel Mageed, Yousra Nomier, Mahmoud A. Elrebehy, Shereen Saeid Elshaer, Mohammed S. Elballal, Osama A. Mohammed^*, Mustafa Ahmed Abdel-Reheim^*, Ahmed S. Doghish^*

^*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلة › Review article

ملخص

microRNAs (miRNAs) play a crucial role in brain growth and function. Hence, research on miRNA has the potential to reveal much about the etiology of neuropsychiatric diseases. Among these, schizophrenia (SZ) is a highly intricate and destructive neuropsychiatric ailment that has been thoroughly researched in the field of miRNA. Despite being a relatively recent area of study about miRNAs and SZ, this discipline has advanced enough to justify numerous reviews that summarize the findings from the past to the present. However, most reviews cannot cover all research, thus it is necessary to synthesize the large range of publications on this topic systematically and understandably. Consequently, this review aimed to provide evidence that miRNAs play a role in the pathophysiology and progression of SZ. They have also been investigated for their potential use as biomarkers and therapeutic targets.

اللغة الأصلية	English
رقم المقال	155102
دورية	Pathology Research and Practice
مستوى الصوت	254
المعرِّفات الرقمية للأشياء	https://doi.org/10.1016/j.prp.2024.155102
حالة النشر	Published - فبراير 1 2024
منشور خارجيًا	نعم

ASJC Scopus subject areas

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الوصول إلى المستند

10.1016/j.prp.2024.155102

الملفات والروابط الأخرى

قم بذكر هذا

Zaki, M. B., Abulsoud, A. I., Ashraf, A., Abdelmaksoud, N. M., Sallam, A. A. M., Aly, S. H., Sa'eed El-Tokhy, F., Rashad, A. A., El-Dakroury, W. A., Abdel Mageed, S. S., Nomier, Y., Elrebehy, M. A., Elshaer, S. S., Elballal, M. S., Mohammed, O. A., Abdel-Reheim, M. A., & Doghish, A. S. (2024). The potential role of miRNAs in the pathogenesis of schizophrenia – A focus on signaling pathways interplay. Pathology Research and Practice, 254, المقال 155102. https://doi.org/10.1016/j.prp.2024.155102

Zaki, MB, Abulsoud, AI, Ashraf, A, Abdelmaksoud, NM, Sallam, AAM, Aly, SH, Sa'eed El-Tokhy, F, Rashad, AA, El-Dakroury, WA, Abdel Mageed, SS, Nomier, Y, Elrebehy, MA, Elshaer, SS, Elballal, MS, Mohammed, OA, Abdel-Reheim, MA & Doghish, AS 2024, 'The potential role of miRNAs in the pathogenesis of schizophrenia – A focus on signaling pathways interplay', Pathology Research and Practice, المجلد 254, 155102. https://doi.org/10.1016/j.prp.2024.155102

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title = "The potential role of miRNAs in the pathogenesis of schizophrenia – A focus on signaling pathways interplay",

abstract = "microRNAs (miRNAs) play a crucial role in brain growth and function. Hence, research on miRNA has the potential to reveal much about the etiology of neuropsychiatric diseases. Among these, schizophrenia (SZ) is a highly intricate and destructive neuropsychiatric ailment that has been thoroughly researched in the field of miRNA. Despite being a relatively recent area of study about miRNAs and SZ, this discipline has advanced enough to justify numerous reviews that summarize the findings from the past to the present. However, most reviews cannot cover all research, thus it is necessary to synthesize the large range of publications on this topic systematically and understandably. Consequently, this review aimed to provide evidence that miRNAs play a role in the pathophysiology and progression of SZ. They have also been investigated for their potential use as biomarkers and therapeutic targets.",

keywords = "Biomarker, Diagnosis, Dopamine system, GABA system, MiRNA, Schizophrenia",

author = "Zaki, {Mohamed Bakr} and Abulsoud, {Ahmed I.} and Alaa Ashraf and Abdelmaksoud, {Nourhan M.} and Sallam, {Al Aliaa M.} and Aly, {Shaza H.} and {Sa'eed El-Tokhy}, Fatma and Rashad, {Ahmed A.} and El-Dakroury, {Walaa A.} and {Abdel Mageed}, {Sherif S.} and Yousra Nomier and Elrebehy, {Mahmoud A.} and Elshaer, {Shereen Saeid} and Elballal, {Mohammed S.} and Mohammed, {Osama A.} and Abdel-Reheim, {Mustafa Ahmed} and Doghish, {Ahmed S.}",

year = "2024",

month = feb,

day = "1",

doi = "10.1016/j.prp.2024.155102",

language = "English",

volume = "254",

journal = "Pathology Research and Practice",

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T1 - The potential role of miRNAs in the pathogenesis of schizophrenia – A focus on signaling pathways interplay

AU - Zaki, Mohamed Bakr

AU - Abulsoud, Ahmed I.

AU - Ashraf, Alaa

AU - Abdelmaksoud, Nourhan M.

AU - Sallam, Al Aliaa M.

AU - Aly, Shaza H.

AU - Sa'eed El-Tokhy, Fatma

AU - Rashad, Ahmed A.

AU - El-Dakroury, Walaa A.

AU - Abdel Mageed, Sherif S.

AU - Nomier, Yousra

AU - Elrebehy, Mahmoud A.

AU - Elshaer, Shereen Saeid

AU - Elballal, Mohammed S.

AU - Mohammed, Osama A.

AU - Abdel-Reheim, Mustafa Ahmed

AU - Doghish, Ahmed S.

PY - 2024/2/1

Y1 - 2024/2/1

N2 - microRNAs (miRNAs) play a crucial role in brain growth and function. Hence, research on miRNA has the potential to reveal much about the etiology of neuropsychiatric diseases. Among these, schizophrenia (SZ) is a highly intricate and destructive neuropsychiatric ailment that has been thoroughly researched in the field of miRNA. Despite being a relatively recent area of study about miRNAs and SZ, this discipline has advanced enough to justify numerous reviews that summarize the findings from the past to the present. However, most reviews cannot cover all research, thus it is necessary to synthesize the large range of publications on this topic systematically and understandably. Consequently, this review aimed to provide evidence that miRNAs play a role in the pathophysiology and progression of SZ. They have also been investigated for their potential use as biomarkers and therapeutic targets.

AB - microRNAs (miRNAs) play a crucial role in brain growth and function. Hence, research on miRNA has the potential to reveal much about the etiology of neuropsychiatric diseases. Among these, schizophrenia (SZ) is a highly intricate and destructive neuropsychiatric ailment that has been thoroughly researched in the field of miRNA. Despite being a relatively recent area of study about miRNAs and SZ, this discipline has advanced enough to justify numerous reviews that summarize the findings from the past to the present. However, most reviews cannot cover all research, thus it is necessary to synthesize the large range of publications on this topic systematically and understandably. Consequently, this review aimed to provide evidence that miRNAs play a role in the pathophysiology and progression of SZ. They have also been investigated for their potential use as biomarkers and therapeutic targets.

KW - Biomarker

KW - Diagnosis

KW - Dopamine system

KW - GABA system

KW - MiRNA

KW - Schizophrenia

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