Temporal variations of lipid peroxidation products, antioxidants and liver marker enzymes in experimental hyperammonemic rats

M. Mohamed Essa, P. Subramanian*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمقالمراجعة النظراء

5 اقتباسات (Scopus)

ملخص

Circadian variations of lipid peroxidation products: thiobarbituric acid and reactive substances (TBARS), antioxidants: reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and liver marker enzymes such as transaminases (aspartate transaminase (AST) and alanine transaminase (ALT), alkaline phosphatase (ALP) and γ-Glutamyl transpeptidase (GGT) in circulation were analysed in control and ammonium chloride (AC) induced (100 mg/kg bodyweight) hyperammonemic rats. Elevated lipid peroxidation and liver marker enzymes (increased mesor of TBARS, AST, ALT, ALP and GGT) associated with decreased activities of antioxidants (decreased mesor of GPx, GSH, SOD and CAT) were found in hyperammonemic rats. Variations in acrophase, amplitude and r values were also found in between the control and hyperammonemic rats. These alterations clearly indicate that temporal liver marker enzymes and redox status are modulated during hyperammonemic conditions, which may also play a crucial role in disease development.

اللغة الأصليةEnglish
الصفحات (من إلى)327-332
عدد الصفحات6
دوريةBiological Rhythm Research
مستوى الصوت38
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أغسطس 2007
منشور خارجيًانعم

ASJC Scopus subject areas

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