Ru-Catalyzed C(sp2)−H Bond Arylation of Benzamides Bearing a Novel 4-Aminoantipyrine as a Directing Group

Hamad H. Al Mamari; Diana Al Kiumi; Tamadher Al Rashdi; Huda Al Quraini; Malak Al Rashdi; Sumayya Al Sheraiqi; Sara Al Harmali; Mohammed Al Lamki; Ahmed Al Sheidi; Asma Al Zadjali

doi:10.1002/ejoc.202100513

Ru-Catalyzed C(sp²)−H Bond Arylation of Benzamides Bearing a Novel 4-Aminoantipyrine as a Directing Group

Hamad H. Al Mamari^*, Diana Al Kiumi, Tamadher Al Rashdi, Huda Al Quraini, Malak Al Rashdi, Sumayya Al Sheraiqi, Sara Al Harmali, Mohammed Al Lamki, Ahmed Al Sheidi, Asma Al Zadjali

^*المؤلف المقابل لهذا العمل

Chemistry

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

ملخص

A novel design-based removable N,O-bidentate directing group based on cheap and commercially available 4-aminoantipyrine (AAP) is reported. Aromatic AP amides bearing 4-aminoantipyrine underwent efficient Ru-catalyzed C(sp²)−H arylation using [RuCl₂(PPh₃)₃] as a catalyst and aryl bromides as electrophiles. The novel bidentate directing group enabled the C−H functionalization reaction with good scope, good functional group tolerance and in decent yields.

اللغة الأصلية	English
الصفحات (من إلى)	3598-3603
عدد الصفحات	6
دورية	European Journal of Organic Chemistry
مستوى الصوت	2021
رقم الإصدار	25
المعرِّفات الرقمية للأشياء	https://doi.org/10.1002/ejoc.202100513
حالة النشر	Published - يوليو 7 2021

ASJC Scopus subject areas

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الوصول إلى المستند

10.1002/ejoc.202100513

الملفات والروابط الأخرى

قم بذكر هذا

Al Mamari, H. H., Al Kiumi, D., Al Rashdi, T., Al Quraini, H., Al Rashdi, M., Al Sheraiqi, S., Al Harmali, S., Al Lamki, M., Al Sheidi, A., & Al Zadjali, A. (2021). Ru-Catalyzed C(sp²)−H Bond Arylation of Benzamides Bearing a Novel 4-Aminoantipyrine as a Directing Group. European Journal of Organic Chemistry, 2021(25), 3598-3603. https://doi.org/10.1002/ejoc.202100513

Ru-Catalyzed C(sp²)−H Bond Arylation of Benzamides Bearing a Novel 4-Aminoantipyrine as a Directing Group. / Al Mamari, Hamad H.; Al Kiumi, Diana; Al Rashdi, Tamadher وآخرون.
في: European Journal of Organic Chemistry, المجلد 2021, رقم 25, ٠٧.٠٧.٢٠٢١, صفحة 3598-3603.

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

Al Mamari, HH, Al Kiumi, D, Al Rashdi, T, Al Quraini, H, Al Rashdi, M, Al Sheraiqi, S, Al Harmali, S, Al Lamki, M, Al Sheidi, A & Al Zadjali, A 2021, 'Ru-Catalyzed C(sp²)−H Bond Arylation of Benzamides Bearing a Novel 4-Aminoantipyrine as a Directing Group', European Journal of Organic Chemistry, المجلد 2021, رقم 25, الصفحات 3598-3603. https://doi.org/10.1002/ejoc.202100513

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abstract = "A novel design-based removable N,O-bidentate directing group based on cheap and commercially available 4-aminoantipyrine (AAP) is reported. Aromatic AP amides bearing 4-aminoantipyrine underwent efficient Ru-catalyzed C(sp2)−H arylation using [RuCl2(PPh3)3] as a catalyst and aryl bromides as electrophiles. The novel bidentate directing group enabled the C−H functionalization reaction with good scope, good functional group tolerance and in decent yields.",

keywords = "4-Aminoantipyrine, Chelation Assistance, C−H Functionalization, Directing group, Ru-Catalysis",

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AU - Al Mamari, Hamad H.

AU - Al Kiumi, Diana

AU - Al Rashdi, Tamadher

AU - Al Quraini, Huda

AU - Al Rashdi, Malak

AU - Al Sheraiqi, Sumayya

AU - Al Harmali, Sara

AU - Al Lamki, Mohammed

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AU - Al Zadjali, Asma

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AB - A novel design-based removable N,O-bidentate directing group based on cheap and commercially available 4-aminoantipyrine (AAP) is reported. Aromatic AP amides bearing 4-aminoantipyrine underwent efficient Ru-catalyzed C(sp2)−H arylation using [RuCl2(PPh3)3] as a catalyst and aryl bromides as electrophiles. The novel bidentate directing group enabled the C−H functionalization reaction with good scope, good functional group tolerance and in decent yields.

KW - 4-Aminoantipyrine

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KW - C−H Functionalization

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KW - Ru-Catalysis

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