Papaya epicarp extract protects against aluminum-induced neurotoxicity

Mostafa I. Waly, Nejib Guizani, Amanat Ali, Mohammad Shafiur Rahman

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

9 اقتباسات (Scopus)


In a previous study, we demonstrated the ability of papaya epicarp extract (PEE) to protect against oxidative stress-induced insult in human SH-SY5Y neuronal cells in a mechanism that appeared to be by means of PEE potent antioxidant properties. To further understand this relationship, we examined the effect of PEE intervention on aluminum (Al)-induced cytotoxicity in SH-SY5Y cells. The results indicated that PEE was effective in protecting against Al-induced cell death in a dose-dependent manner. PEE restored the Al-induced inhibition of folate-dependent methionine synthase activity and the antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). PEE ameliorated the Al-induced impairment of intracellular glutathione and total antioxidant capacity. Together, these findings indicate that PEE supplementation can play a neuroprotective role in ameliorating the changes in redox status of SH-SY5Y cells exposed to Al, a wellknown environmental toxin that is involved in the pathogenesis of neurodegenerative diseases and neurodevelopmental disorders.

اللغة الأصليةEnglish
الصفحات (من إلى)1018-1022
عدد الصفحات5
دوريةExperimental Biology and Medicine
مستوى الصوت237
رقم الإصدار9
المعرِّفات الرقمية للأشياء
حالة النشرPublished - سبتمبر 1 2012

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