Purpose: The purpose of this study was twofold: (a) to assess predictors of the turnover intention, burnout, and perceived quality of care among nurses working in Oman, and (b) to examine the potential moderating role of job satisfaction on the relationship between work environment and nurse turnover intention. Design: A cross-sectional design was used to collect data from a sample of 207 nurses working in a public hospital in Muscat, Oman. Methods: An electronic survey was used to assess nurses’ perceptions of work environment, burnout, job satisfaction, turnover intention, and quality of care. Findings: Participation in hospital affairs, a foundation for quality of care, and staffing adequacy were predictors of burnout among nurses and perceived quality of care. Logistic regression analysis revealed that working in a favorable environment was associated with less turnover intention, but only when job satisfaction was high. Conclusions: Improving nurse job satisfaction is a mechanism through which future interventions could enhance working conditions and promote better nurse retention. Clinical Relevance: Organizational strategies are needed to increase nurse job satisfaction by empowering nurses to take more active roles in hospital affairs as a strategy to reduce turnover intention and enhance the quality of patient care.