TY - JOUR
T1 - Nickel oxide hollow microsphere for the chemiluminescence determination of tuberculostatic drug isoniazid
AU - Hassanpour-Khaneghah, Mahdiyeh
AU - Iranifam, Mortaza
AU - Naseri, Abdolhossein
AU - Al Lawati, Haider A.J.
N1 - Funding Information:
The authors thank the University of Maragheh and the University of Tabriz for all the support provided. The authors wish to acknowledge the Management of Research and Technology and the Central Laboratory of the University of Maragheh for their help in running the experiments.
Publisher Copyright:
© 2022 John Wiley & Sons Ltd.
PY - 2022/7
Y1 - 2022/7
N2 - In this article, nickel(II) oxide (NiO) hollow microspheres (HMSs) were fabricated and used to catalyze chemiluminescence (CL) reaction. The studied CL reaction is the luminol-oxygen reaction that was used as a sensitive analytical tool for measuring tuberculostatic drug isoniazid (IND) in pharmaceutical formulations and water samples. The CL method was established based on the suppression impact of IND on the CL reaction. The NiO HMSs were produced by a simple hydrothermal method and characterized by several spectroscopic techniques. The result of essential parameters on the analytical performance of the CL method, including concentrations of sodium hydroxide (NaOH), luminol, and NiO HMSs were investigated. At the optimum conditions, the calibration curve for IND was linear in the range of 8.00 × 10−7 to 1.00 × 10−4 mol L−1 (R2 = 0.99). A detection limit (3S) of 2.00 × 10−7 mol L−1 was obtained for this method. The acceptable relative standard deviation (RSD) was obtained for the proposed CL method (2.63%, n = 10) for a 5.00 × 10−6 mol L−1 IND solution. The mechanism of the CL reaction was also discussed.
AB - In this article, nickel(II) oxide (NiO) hollow microspheres (HMSs) were fabricated and used to catalyze chemiluminescence (CL) reaction. The studied CL reaction is the luminol-oxygen reaction that was used as a sensitive analytical tool for measuring tuberculostatic drug isoniazid (IND) in pharmaceutical formulations and water samples. The CL method was established based on the suppression impact of IND on the CL reaction. The NiO HMSs were produced by a simple hydrothermal method and characterized by several spectroscopic techniques. The result of essential parameters on the analytical performance of the CL method, including concentrations of sodium hydroxide (NaOH), luminol, and NiO HMSs were investigated. At the optimum conditions, the calibration curve for IND was linear in the range of 8.00 × 10−7 to 1.00 × 10−4 mol L−1 (R2 = 0.99). A detection limit (3S) of 2.00 × 10−7 mol L−1 was obtained for this method. The acceptable relative standard deviation (RSD) was obtained for the proposed CL method (2.63%, n = 10) for a 5.00 × 10−6 mol L−1 IND solution. The mechanism of the CL reaction was also discussed.
KW - NiO hollow microsphere
KW - chemiluminescence
KW - isoniazid
KW - luminol
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U2 - 10.1002/bio.4273
DO - 10.1002/bio.4273
M3 - Article
C2 - 35567303
AN - SCOPUS:85131153232
SN - 1522-7235
VL - 37
SP - 1184
EP - 1191
JO - Luminescence
JF - Luminescence
IS - 7
ER -