NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations

Mansour Al-Moundhri, Mohamed Al-Kindi, Maryam Al-Nabhani, Bassim Al-Bahrani, Ikram A. Burney, Ali Al-Madhani, Shyam S. Ganguly, Misbah Tanira

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

15 اقتباسات (Scopus)


Aim: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. Methods: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. Results: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. Conclusion: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.

اللغة الأصليةEnglish
الصفحات (من إلى)2697-2702
عدد الصفحات6
دوريةWorld Journal of Gastroenterology
مستوى الصوت13
رقم الإصدار19
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مايو 21 2007

ASJC Scopus subject areas

  • ???subjectarea.asjc.2700.2715???


أدرس بدقة موضوعات البحث “NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا