Multiple Myeloma: Challenges Encountered and Future Options for Better Treatment

Srijit Das, Norsham Juliana*, Noor Anisah Abu Yazit, Sahar Azmani, Izuddin Fahmy Abu

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةReview articleمراجعة النظراء

13 اقتباسات (Scopus)


Multiple myeloma (MM) is a malignant hematological disease. The disease is character-ized by the clonal proliferation of malignant plasma cells in the bone marrow. MM accounts for 1.3% of all malignancies and has been increasing in incidence all over the world. Various genetic abnormalities, mutations, and translocation, including epigenetic modifications, are known to con-tribute to the disease’s pathophysiology. The prognosis is good if detected early, or else the outcome is very bad if distant metastasis has already occurred. Conventional treatment with drugs poses a challenge when there is drug resistance. In the present review, we discuss multiple myeloma and its treatment, drug resistance, the molecular basis of epigenetic regulation, the role of natural products in epigenetic regulators, diet, physical activity, addiction, and environmental pollutants, which may be beneficial for clinicians and researchers.

اللغة الأصليةEnglish
رقم المقال1649
دوريةInternational Journal of Molecular Sciences
مستوى الصوت23
رقم الإصدار3
المعرِّفات الرقمية للأشياء
حالة النشرPublished - فبراير 1 2022

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