TY - JOUR
T1 - miRNAs orchestration of gallbladder cancer – Particular emphasis on diagnosis, progression and drug resistance
AU - Shahin, Reem K.
AU - Elkady, Mohamed A.
AU - Abulsoud, Ahmed I.
AU - Abdelmaksoud, Nourhan M.
AU - Abdel Mageed, Sherif S.
AU - El-Dakroury, Walaa A.
AU - Zewail, Moataz B.
AU - Elazazy, Mahmoud
AU - Sobhy, Mohamed H.
AU - Nomier, Yousra
AU - Elazazy, Ola
AU - Elballal, Mohammed S.
AU - Mohammed, Osama A.
AU - Midan, Heba M.
AU - Elrebehy, Mahmoud A.
AU - Ziada, Bassant O.
AU - Doghish, Ahmed S.
N1 - Publisher Copyright:
© 2023 Elsevier GmbH
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Gallbladder cancer (GBC) is characterized by a highly invasive nature and a poor prognosis, with adenocarcinoma being the main histological subtype. According to statistical data, patients diagnosed with advanced GBC have a survival rate of less than 5% for 5 years. Despite the novel therapeutic techniques, the unsatisfactory results could be related to the underlying biology of tumor cells and resistance to chemotherapy. Early diagnosis is more important than clinical therapy as it assists in determining the pathological stage of cancer and facilitates the selection of appropriate medication. Hence, it is very important to understand the precise pathogenesis of GBC and to discover potential novel biomarkers for early diagnosis of GBC. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, have been found to influence the transcriptional regulation of target genes associated with cancer, either directly or indirectly. microRNAs are a group of small, non-coding, single-stranded RNAs that are expressed endogenously. miRNAs play significant roles in various fundamental cellular processes. Therefore, miRNAs have the potential to serve as valuable biomarkers and therapeutic targets for GBC.
AB - Gallbladder cancer (GBC) is characterized by a highly invasive nature and a poor prognosis, with adenocarcinoma being the main histological subtype. According to statistical data, patients diagnosed with advanced GBC have a survival rate of less than 5% for 5 years. Despite the novel therapeutic techniques, the unsatisfactory results could be related to the underlying biology of tumor cells and resistance to chemotherapy. Early diagnosis is more important than clinical therapy as it assists in determining the pathological stage of cancer and facilitates the selection of appropriate medication. Hence, it is very important to understand the precise pathogenesis of GBC and to discover potential novel biomarkers for early diagnosis of GBC. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, have been found to influence the transcriptional regulation of target genes associated with cancer, either directly or indirectly. microRNAs are a group of small, non-coding, single-stranded RNAs that are expressed endogenously. miRNAs play significant roles in various fundamental cellular processes. Therefore, miRNAs have the potential to serve as valuable biomarkers and therapeutic targets for GBC.
KW - Diagnosis
KW - Drug resistance
KW - Gall bladder cancer
KW - GBC
KW - MiRNA
KW - Prognosis
KW - MicroRNAs/genetics
KW - Humans
KW - Carcinoma in Situ
KW - Gene Expression Regulation, Neoplastic/genetics
KW - Gallbladder Neoplasms/diagnosis
KW - Drug Resistance
UR - http://www.scopus.com/inward/record.url?scp=85165061783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85165061783&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/b95c3d3c-a1ce-384a-91b3-44d1b38d1e25/
U2 - 10.1016/j.prp.2023.154684
DO - 10.1016/j.prp.2023.154684
M3 - Review article
C2 - 37454489
AN - SCOPUS:85165061783
SN - 0344-0338
VL - 248
JO - Pathology Research and Practice
JF - Pathology Research and Practice
M1 - 154684
ER -