TY - JOUR
T1 - miRNAs as modulators of neuroinflammation and excitotoxicity
T2 - Implications for stroke therapeutics
AU - Elballal, Mohammed S.
AU - Mohammed, Osama A.
AU - Zaki, Mohamed Bakr
AU - Abulsoud, Ahmed I.
AU - Tabaa, Manar Mohammed El
AU - Elazazy, Ola
AU - Abd-Elmawla, Mai A.
AU - El-Dakroury, Walaa A.
AU - Abdel Mageed, Sherif S.
AU - Rashad, Ahmed A.
AU - Abdelmaksoud, Nourhan M.
AU - Elrebehy, Mahmoud A.
AU - Nomier, Yousra
AU - Abdel-Reheim, Mustafa Ahmed
AU - Oraby, Mamdouh A.
AU - Doghish, Ahmed S.
N1 - Copyright © 2024 Elsevier GmbH. All rights reserved.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Stroke is a widespread neurological disorder associated with physical disabilities, mortality, and economic burden. In recent decades, substantial progress has been achieved in reducing the impact of this public health problem. However, further understanding of the pathophysiology of stroke and the underlying genetic pathways is required. The pathological mechanisms of stroke comprise multifaceted molecular cascades regulated by various microRNAs (miRNAs). An increasing number of studies have highlighted the role of miRNAs, which have received much attention during the last decades as an important class of post-transcriptional regulators. It was shown that miRNAs exert their role in the etiology of stroke via mediating excitotoxicity and neuroinflammation. Additionally, miRNAs could be helpful as non-invasive or minimally invasive biomarkers and therapeutic agents. Thus, the current review focused on the interplay of these miRNAs in stroke pathology to upgrade the existing therapeutic strategies.
AB - Stroke is a widespread neurological disorder associated with physical disabilities, mortality, and economic burden. In recent decades, substantial progress has been achieved in reducing the impact of this public health problem. However, further understanding of the pathophysiology of stroke and the underlying genetic pathways is required. The pathological mechanisms of stroke comprise multifaceted molecular cascades regulated by various microRNAs (miRNAs). An increasing number of studies have highlighted the role of miRNAs, which have received much attention during the last decades as an important class of post-transcriptional regulators. It was shown that miRNAs exert their role in the etiology of stroke via mediating excitotoxicity and neuroinflammation. Additionally, miRNAs could be helpful as non-invasive or minimally invasive biomarkers and therapeutic agents. Thus, the current review focused on the interplay of these miRNAs in stroke pathology to upgrade the existing therapeutic strategies.
KW - Excitotoxicity
KW - MiRNA
KW - Neuroinflammation
KW - Non-invasive biomarkers
KW - Stroke
KW - Therapeutic intervention
UR - http://www.scopus.com/inward/record.url?scp=85181809960&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85181809960&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/6e21ab68-c286-3938-90d0-bd6a050c7f87/
U2 - 10.1016/j.prp.2024.155093
DO - 10.1016/j.prp.2024.155093
M3 - Article
C2 - 38184962
AN - SCOPUS:85181809960
SN - 0344-0338
VL - 253
SP - 155093
JO - Pathology Research and Practice
JF - Pathology Research and Practice
M1 - 155093
ER -