TY - JOUR
T1 - miRNA-regulated cancer stem cells
T2 - understanding the property and the role of miRNA in carcinogenesis
AU - Chakraborty, Chiranjib
AU - Chin, Kok Yong
AU - Das, Srijit
N1 - Publisher Copyright:
© 2016, International Society of Oncology and BioMarkers (ISOBM).
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.
AB - Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.
KW - Migration
KW - Stem cell
KW - Therapy
KW - Tumor
KW - miRNA
UR - http://www.scopus.com/inward/record.url?scp=84979986065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84979986065&partnerID=8YFLogxK
U2 - 10.1007/s13277-016-5156-1
DO - 10.1007/s13277-016-5156-1
M3 - Review article
C2 - 27468722
AN - SCOPUS:84979986065
SN - 1010-4283
VL - 37
SP - 13039
EP - 13048
JO - Tumor Biology
JF - Tumor Biology
IS - 10
ER -