Micro-RNA and the features of metabolic syndrome: A narrative review

Srijit Das*, Isa Naina Mohamed, Seong Lin Teoh, Tarrsini Thevaraj, Ku Nurmahirah Ku Ahmad Nasir, Azwani Zawawi, Hazwan Hazrin Salim, Dennis Kheng Zhou

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةReview articleمراجعة النظراء

10 اقتباسات (Scopus)


The incidence of metabolic syndrome (MetS) has risen globally. MetS includes a combination of features, i.e. blood glucose impairment, excess abdominal/body fat dyslipidemia and elevated blood pressure. Other than conventional treatment with drugs, the main preventive approaches include lifestyle changes, weight loss, diet control and adequate exercise also proves to be beneficial. MicroRNAs (miRNAs) are small non-coding RNAs that play critical regulatory roles in most biological and pathological processes. In the present review, we discuss various miRNAs which are related to MetS by targeting various organs, including the pancreas, liver, skeletal muscles and adipose tissues. These miRNAs have the effect on insulin production and secretion (miR-9, miR-124a, miR-130a,b, miR152, miR-335, miR-375), insulin resistance (miR-29), adipogenesis (miR-143, miR148a) and lipid metabolism (miR-192). We also discuss the miRNAs as potential biomarkers and future therapeutic targets. This review may be beneficial for molecular biologists and clinicians dealing with MetS.

اللغة الأصليةEnglish
الصفحات (من إلى)626-635
عدد الصفحات10
دوريةMini-Reviews in Medicinal Chemistry
مستوى الصوت20
رقم الإصدار7
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 2020

ASJC Scopus subject areas

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