LACK OF EFFECT OF CHLORAMPHENICOL ON MONOAMINE, DIAMINE AND PLASMA AMINE OXIDASE ACTIVITIES

1. Chloramphenicol treatment in rabbits (60 mg/kg i.m. for 5 days) did not affect significantly (P > 0.1) the activities of monoamine oxidase (MAO) or diamine oxidase (DAO) in liver, heart or brain. 2. Plasma amine oxidase (PAO) was not significantly inhibited (P>0.1) in goats treated with chloramphenicol (60 mg/kg i.m. for 5 days). 3. Chloramphenicol (2×10⁻³ mol/l) preincubated with rabbit hepatic MAO had no significant effect (P>0.1) on the enzyme activity.