TY - JOUR
T1 - Isolation and Identification of Phytocompounds from Maytenus dhofarensis and Their Biological Potentials
AU - Al-Rubaiai, Fatma
AU - Al-Shariqi, Zakiya Zahran
AU - Al-Shabibi, Khalsa S.
AU - Husband, John
AU - Al-Hattali, Asmaa M.
AU - Goettert, Marcia
AU - Laufer, Stefan
AU - Baqi, Younis
AU - Hassan, Syed Imran
AU - Fatope, Majekodunmi O.
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/8/15
Y1 - 2023/8/15
N2 - Maytenus dhofarensis Sebsebe (Celestraceae) is a naturally growing shrub in Oman. It is not a reputed medicinal plant in Oman, but it is regionally endemic and causes shivering attacks on goats that graze on it. The chemical investigation of the hexane and chloroform extracts of the fruits and stems of M. dhofarensis afforded dihydro-β-agarofuran-type sesquiterpene pyridine alkaloid (1), lupanyl myristoate (2) and lignanolactone (3). Compounds (1–3) are new isolates from M. dhofarensis. The structures of these compounds were assigned through comprehensive IR, NMR, and ESI-MS analyses, and the relative configurations of compounds 1 and 3 were deduced from density function theory (DFT) calculations and NMR experiments. Compound 1 was assayed against the kinase enzyme and showed no inhibition activity for p38 alpha and delta at a 10 µM test concentration. Compound 3 inhibited the 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH) by 69.5%, compared to 70.9% and 78.0% for gallic acid and butylated hydroxyanisole, respectively, which were used as positive controls.
AB - Maytenus dhofarensis Sebsebe (Celestraceae) is a naturally growing shrub in Oman. It is not a reputed medicinal plant in Oman, but it is regionally endemic and causes shivering attacks on goats that graze on it. The chemical investigation of the hexane and chloroform extracts of the fruits and stems of M. dhofarensis afforded dihydro-β-agarofuran-type sesquiterpene pyridine alkaloid (1), lupanyl myristoate (2) and lignanolactone (3). Compounds (1–3) are new isolates from M. dhofarensis. The structures of these compounds were assigned through comprehensive IR, NMR, and ESI-MS analyses, and the relative configurations of compounds 1 and 3 were deduced from density function theory (DFT) calculations and NMR experiments. Compound 1 was assayed against the kinase enzyme and showed no inhibition activity for p38 alpha and delta at a 10 µM test concentration. Compound 3 inhibited the 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH) by 69.5%, compared to 70.9% and 78.0% for gallic acid and butylated hydroxyanisole, respectively, which were used as positive controls.
KW - biological activities
KW - Maytenus dhofarensis
KW - secondary metabolites
KW - Animals
KW - Chloroform
KW - Fruit
KW - Goats
KW - Maytenus
KW - Biological Assay
KW - Butylated Hydroxyanisole
UR - http://www.scopus.com/inward/record.url?scp=85168745466&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85168745466&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/ab7e04fd-4f0a-3907-b54d-a46b44d55185/
U2 - 10.3390/molecules28166077
DO - 10.3390/molecules28166077
M3 - Article
C2 - 37630328
AN - SCOPUS:85168745466
SN - 1420-3049
VL - 28
JO - Molecules
JF - Molecules
IS - 16
M1 - 6077
ER -