The Proterozoic basement of the Dhofar region of Oman may be a potential source and trap for uranium and associated minerals as 30%-40% of the global production of Uranium comes from Proterozoic basins (Canada). Further, the reconnaissance surveys carried out during the late 1970s suggest the possibility of Uranium occurrence in this region. The emphasis (area of interest) for further detailed investigation lies on increased radiation levels for which the Neoproterozoic rocks of southern Oman and some members of the Huqf Supergroup in Al Wasta region can be considered as the major hosts for potential Uranium enrichment. An association of evaporates, C-rich shales, and accumulated hydrocarbons, presents a perfect geochemical trap for an initial concentration of elements such as Uranium, from where successive redistribution processes may lead to a Uranium enrichment/mineralization in a particular strata. Accordingly, a detailed geological, geochemical and geophysical investigations were carried out in the recent past in a selected couple of areas. The acquired geophysical data such as Radiometric, Magnetic and VLF-EM (Very low frequency electromagnetic) were processed and interpreted in addition to in situ XRF analysis and geochemical laboratory investigation are presented.