TY - JOUR
T1 - Influence of Hibiscus sabdariffa (Gongura) on the levels of circulatory lipid peroxidation products and liver marker enzymes in experimental hyperammonemia
AU - Essa, Musthafa Mohamed
AU - Subramanian, Perumal
AU - Suthakar, Ganapathy
AU - Manivasagam, Tamilarasan
AU - Dakshayani, Kadiyala Babu
AU - Sivaperumal, Ramar
AU - Subash, Selvaraju
AU - Vinothini, Govindarajaha
PY - 2006/3
Y1 - 2006/3
N2 - Hibiscus sabdariffa (Linn) (family Malvaceae), is an annual dicotyledonous herbaceous shrub plant popularly known as 'Gongura' in Hindi or 'Pulicha keerai' in Tamil, which is an indigenous edible medicinal plant used in Ayurvedic Medicine in India, China and Thailand. We have investigated the influence of Hibiscus sabdariffa leaf extract (HSEt) on the levels of circulatory ammonia, urea, lipid peroxidation products such as TBARS (thiobarbituric acid and reactive substances), HP (hydroperoxides) and liver marker enzymes such as AST (aspartate transaminase), ALT (alanine transaminase) and ALP (alkaline phosphatase), for its hepatoprotective effect in ammonium chloride induced hyperammonemia. Ammonium chloride treated rats showed a significant increase in the levels of circulatory ammonia, urea, AST, ALT, ALP, TBARS and HP. These changes were significantly decreased in rats treated with HSEt and ammonium chloride. Our results indicate that HSEt offers hepatoprotection by influencing the levels of lipid peroxidation products and liver markers in experimental hyperammonemia and this could be due to its free radical scavenging property and the presence of natural antioxidants. The exact mechanism has to be still investigated and the isolation of active constituents is required.
AB - Hibiscus sabdariffa (Linn) (family Malvaceae), is an annual dicotyledonous herbaceous shrub plant popularly known as 'Gongura' in Hindi or 'Pulicha keerai' in Tamil, which is an indigenous edible medicinal plant used in Ayurvedic Medicine in India, China and Thailand. We have investigated the influence of Hibiscus sabdariffa leaf extract (HSEt) on the levels of circulatory ammonia, urea, lipid peroxidation products such as TBARS (thiobarbituric acid and reactive substances), HP (hydroperoxides) and liver marker enzymes such as AST (aspartate transaminase), ALT (alanine transaminase) and ALP (alkaline phosphatase), for its hepatoprotective effect in ammonium chloride induced hyperammonemia. Ammonium chloride treated rats showed a significant increase in the levels of circulatory ammonia, urea, AST, ALT, ALP, TBARS and HP. These changes were significantly decreased in rats treated with HSEt and ammonium chloride. Our results indicate that HSEt offers hepatoprotection by influencing the levels of lipid peroxidation products and liver markers in experimental hyperammonemia and this could be due to its free radical scavenging property and the presence of natural antioxidants. The exact mechanism has to be still investigated and the isolation of active constituents is required.
KW - ALP
KW - ALT
KW - AST
KW - Ammonium chloride
KW - Hyperammonemia
KW - Lipid peroxidation
KW - Urea
UR - http://www.scopus.com/inward/record.url?scp=33344479373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33344479373&partnerID=8YFLogxK
U2 - 10.32725/jab.2006.004
DO - 10.32725/jab.2006.004
M3 - Article
AN - SCOPUS:33344479373
SN - 1214-021X
VL - 4
SP - 53
EP - 58
JO - Journal of Applied Biomedicine
JF - Journal of Applied Biomedicine
IS - 1
ER -