Improved synthesis of 4-/6-substituted 2-carboxy-1H-indole-3-propionic acid derivatives and structure-activity relationships as GPR17 agonists

Pharmacology, Toxicology and Pharmaceutical Science

• Indole 100%
• Propionic Acid 66%
• Myelin 33%
• G Protein Coupled Receptor 33%
• EC50 33%
• Spinal Cord Injury 33%
• Propionic Acid Derivative 33%
• Indolepropionic Acid 33%
• Phenylhydrazone Derivative 33%
• Astrocytoma 33%

Biochemistry, Genetics and Molecular Biology

• Agonist 100%
• Calcium Mobilization 33%
• EC50 33%
• Cope Rearrangement 33%
• Myelin 33%
• G Protein-Coupled Receptor 33%

Agricultural and Biological Sciences

• Agonist 100%
• Spinal Cord 33%