TY - JOUR
T1 - Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake
AU - Jalili-Nik, Mohammad
AU - Mahboobnia, Khadijeh
AU - Guest, Paul C
AU - Majeed, Muhammed
AU - Al-Rasadi, Khalid
AU - Jamialahmadi, Tannaz
AU - Sahebkar, Amirhossein
N1 - © 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/9/3
Y1 - 2021/9/3
N2 - Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.
AB - Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the removal of LDL particles from the plasma, mainly by the liver, is the most efficient strategy for reducing LDL-C and the ensuing atherosclerosis. In this context, polyphenolic compounds like curcumin have generated interest owing to their lipid-modifying capacity. The promising effect of curcumin has been studied in attenuating atherosclerosis (in experimental models), and correcting dyslipidemia (in clinical studies). The underlying mechanisms of the effects of curcumin are relatively unknown, and the impact of curcumin on hepatic LDL uptake warrants further investigations. Here, we present a protocol to assess the effects of curcumin on LDL uptake in hepatocytes.
KW - Atherosclerosis
KW - Cholesterol
KW - Curcumin
KW - Hepatocyte
KW - LDL-C uptake
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UR - https://www.mendeley.com/catalogue/6fe32fb3-004f-3d96-abd7-70f9cbe52f21/
U2 - 10.1007/978-1-0716-1558-4_29
DO - 10.1007/978-1-0716-1558-4_29
M3 - Article
C2 - 34473340
SN - 1064-3745
VL - 2343
SP - 395
EP - 400
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -
