Ifosfamide neurotoxicty in a young female with a remarkable response to Thiamine

Saba Imtiaz*, Narjis Muzaffar

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

11 اقتباسات (Scopus)


Ifosfamide, a commonly used chemotherapeutic agent in various regimens for many malignancies and has a well known central nervous system side effect. Ifosfamide induced encephalopathy develops in approximately 10-30% of patients exposed to the drug. It is generally reversible after discontinuing the therapy; however cases of fatal neurotoxicity have been reported in literature. Commonly used antidote, Methylene blue; has a moderate efficacy in reversing the encephalopathy followed by lesser response rates by Thiamine. We submit a case report of a young female patient with refractory diffuse large B cell lymphoma who developed severe ifosfamide neurotoxicity. With the use of intravenous thiamine, encephalopathy resolved in our patient within a mean time of 30 hours (average range is 10-30 hours). We found Thiamine to be safe and effective in treatment for ifosfamide induced encephalopathy.

اللغة الأصليةEnglish
الصفحات (من إلى)867-869
عدد الصفحات3
دوريةJournal of the Pakistan Medical Association
مستوى الصوت60
رقم الإصدار10
حالة النشرPublished - أكتوبر 2010
منشور خارجيًانعم

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