Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review

Dinah Farhanah Jamal, Quratul Ain Rozaimee, Nadila Haryani Osman, Atikah Mohd Sukor, Marjanu Hikmah Elias, Nor Aripin Shamaan, Srijit Das, Nazefah Abdul Hamid

نتاج البحث: المساهمة في مجلةReview articleمراجعة النظراء


Human papillomavirus type 16 (HPV-16) is a well-known etiological factor for cervical and oropharyngeal cancers. The E2 protein, the product of an early-transcribed gene in HPV-16, is postulated to cause the death of cancerous cells via p53-dependent and p53-independent pathways. The main aim of the present systematic review was to study the HPV 16-E2 protein as an apoptosis-inducer agent. A thorough search of MEDLINE/PubMed, Science Direct, Scopus, and EBSCOhost databases was conducted for relevant studies on HPV AND apoptosis OR cell death where HPV 16-E2 was involved. The search identified 967 publications. Eleven records dated from 1 January 1997 to 16 February 2022 were found to meet the inclusion criteria and were eligible for data extraction and inclusion. All studies concluded that HPV 16-E2 was able to induce cell death in transfected cells. E2 proteins from the high-risk HPV-16 were able to induce apoptosis through different apoptotic pathways depending on the location of the expressed gene. However, the mechanism was still unclear, and further studies are warranted.

اللغة الأصليةEnglish
رقم المقال12554
دوريةInternational Journal of Molecular Sciences
مستوى الصوت23
رقم الإصدار20
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أكتوبر 19 2022

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