High-density lipoproteins and cardiovascular disease: 2010 update

Khalid Alwaili, Zuheir Awan, Ali Alshahrani, Jacques Genest*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةReview articleمراجعة النظراء

35 اقتباسات (Scopus)


High-density lipoprotein-cholesterol (HDL-C) is a continuous inverse cardiovascular risk factor. The mechanisms by which HDLs protect against atherosclerosis are multiple. The major effect is thought to be reverse cholesterol transport, the mechanism by which excess cellular cholesterol is returned to the liver for excretion in the bile. HDLs also have pleiotropic roles: they decrease inflammation, prevent low-density lipoprotein oxidation, vascular endothelial cell apoptosis and thrombosis, and improve vascular endothelial function. Recent studies suggest that nascent HDL particles are metabolized rapidly and that their components (Apo AI, cholesterol and phospholipids) are rapidly exchanged within lipoprotein classes. There are many causes of HDL-C deficiency. Using Mendelian randomization, several groups have concluded that many genetic forms of HDL deficiency do not increase cardiovascular risk. This raises the controversial issue of the causality of low HDL-C as a cardiovascular risk factor, rather than a marker of cardiovascular health. This is reflected in the importance of lifestyle in determining HDL-C levels. The treatment of low HDL-C remains controversial, in part because the only currently available effective medication, niacin, is relatively poorly tolerated and outcomes studies on cardiovascular disease prevention are still pending.

اللغة الأصليةEnglish
الصفحات (من إلى)413-423
عدد الصفحات11
دوريةExpert Review of Cardiovascular Therapy
مستوى الصوت8
رقم الإصدار3
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مارس 2010
منشور خارجيًانعم

ASJC Scopus subject areas

  • ???subjectarea.asjc.2700.2724???
  • ???subjectarea.asjc.2700.2705???


أدرس بدقة موضوعات البحث “High-density lipoproteins and cardiovascular disease: 2010 update'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا