TY - JOUR
T1 - Guillain-Barré Syndrome Associated with SARS-CoV-2 in Two Pediatric Patients
AU - Al amrani, Fatema
AU - Al-Abdwani, Raghad
AU - Al rashdi, Fatma
AU - Al-Ajmi, Eiman
AU - Al futaisi, Amna
N1 - © Copyright 2023, Sultan Qaboos University Medical Journal, All Rights Reserved.
PY - 2023/8/28
Y1 - 2023/8/28
N2 - Guillain-Barré syndrome (GBS) is a recognised complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report two children with GBS associated with SARS-CoV-2 who presented to a tertiary centre in Muscat, Oman in 2021: The first patient was a three-month-old female infant who presented with bradypnea, encephalopathy, and generalised weakness that required mechanical ventilation. Polymerase chain reaction (PCR) testing of the nasopharyngeal swabs (NPS) was positive for SARS-CoV-2. She had axonal variant GBS based on a nerve conduction study, cerebrospinal fluid analysis, and neuroimaging findings. The second patient was a six-year-old girl with fever, vomiting, and diarrhea followed by ascending weakness who presented with quadriplegia and facial weakness. Subsequently, she developed respiratory muscle weakness and required mechanical ventilation. PCR testing of NPS was negative for SARS-Cov-2, however IgG serology analysis was positive. The clinical course of these two patients was rapidly progressive and both of them required mechanical ventilation. The patient with axonal variant GBS made an incomplete recovery. Keywords: Acute Inflammatory Demyelinating Polyradiculoneuropathy; SARS-CoV-2; Case Report; Oman.
AB - Guillain-Barré syndrome (GBS) is a recognised complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report two children with GBS associated with SARS-CoV-2 who presented to a tertiary centre in Muscat, Oman in 2021: The first patient was a three-month-old female infant who presented with bradypnea, encephalopathy, and generalised weakness that required mechanical ventilation. Polymerase chain reaction (PCR) testing of the nasopharyngeal swabs (NPS) was positive for SARS-CoV-2. She had axonal variant GBS based on a nerve conduction study, cerebrospinal fluid analysis, and neuroimaging findings. The second patient was a six-year-old girl with fever, vomiting, and diarrhea followed by ascending weakness who presented with quadriplegia and facial weakness. Subsequently, she developed respiratory muscle weakness and required mechanical ventilation. PCR testing of NPS was negative for SARS-Cov-2, however IgG serology analysis was positive. The clinical course of these two patients was rapidly progressive and both of them required mechanical ventilation. The patient with axonal variant GBS made an incomplete recovery. Keywords: Acute Inflammatory Demyelinating Polyradiculoneuropathy; SARS-CoV-2; Case Report; Oman.
KW - Acute Inflammatory Demyelinating Polyradiculoneuropathy
KW - Case Report
KW - Oman
KW - SARS-CoV-2
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UR - https://www.mendeley.com/catalogue/6502bd48-a88c-34a9-8e56-f738b6a9aa44/
U2 - 10.18295/squmj.5.2022.040
DO - 10.18295/squmj.5.2022.040
M3 - Article
C2 - 37655082
AN - SCOPUS:85172761609
SN - 2075-051X
VL - 23
SP - 400
EP - 404
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
IS - 3
ER -