TY - JOUR
T1 - Forecasting hemoglobinopathy burden through neonatal screening in Omani neonates
AU - Alkindi, Salam
AU - Al Zadjali, Shoaib
AU - Al Madhani, Ali
AU - Daar, Shahina
AU - Al Haddabi, Hamood
AU - Al Abri, Qamariya
AU - Gravell, David
AU - Berbar, Tsouria
AU - Pravin, Sahaya
AU - Pathare, Anil
AU - Krishnamoorthy, Rajagopal
PY - 2010/4
Y1 - 2010/4
N2 - To evaluate the incidence of hemoglobinopathies in Omani subjects and to forecast its future burden on health resources, we initiated a prospective neonatal screening program in two major cities of the Sultanate of Oman. Consecutive cord blood samples from a total of 7,837 neonates were analyzed for complete blood counts and for hemoglobin (Hb) profile by high performance liquid chromatography (HPLC). No case with Hb H (β4) was detected. We observed that the overall incidence of α-thalassemia (α-thal) was 48.5 [based on the presence of Hb Bart's (γ4)] and the β-globin-related abnormalities accounted for 9.5 of the samples (4.8 sickle cell trait, 2.6 β-thal trait, 0.9 Hb E trait, 0.8 Hb D trait, 0.08 Hb C trait, 0.3 sickle cell disease and 0.08 homozygous β-thal). This is also the first large study to establish reference ranges of cord red blood cell (RBC) indices for Omani neonates.
AB - To evaluate the incidence of hemoglobinopathies in Omani subjects and to forecast its future burden on health resources, we initiated a prospective neonatal screening program in two major cities of the Sultanate of Oman. Consecutive cord blood samples from a total of 7,837 neonates were analyzed for complete blood counts and for hemoglobin (Hb) profile by high performance liquid chromatography (HPLC). No case with Hb H (β4) was detected. We observed that the overall incidence of α-thalassemia (α-thal) was 48.5 [based on the presence of Hb Bart's (γ4)] and the β-globin-related abnormalities accounted for 9.5 of the samples (4.8 sickle cell trait, 2.6 β-thal trait, 0.9 Hb E trait, 0.8 Hb D trait, 0.08 Hb C trait, 0.3 sickle cell disease and 0.08 homozygous β-thal). This is also the first large study to establish reference ranges of cord red blood cell (RBC) indices for Omani neonates.
KW - Neonatal screening
KW - Red cell indices
KW - α-Thalassemia (α-thal)Oman
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U2 - 10.3109/03630261003677213
DO - 10.3109/03630261003677213
M3 - Article
C2 - 20353348
AN - SCOPUS:77950495950
SN - 0363-0269
VL - 34
SP - 135
EP - 144
JO - Hemoglobin
JF - Hemoglobin
IS - 2
ER -