Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia

Naglaa A. Fawaz, Layla Bashawery, Iman Al-Sheikh, Ahlam Qatari, Sara S. Al-Othman, Wassim Y. Almawi*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمقالمراجعة النظراء

25 اقتباسات (Scopus)

ملخص

The prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations were investigated among 87 Saudi sickle cell disease (SCD) patients (38 males and 49 females) and 105 healthy controls (65 males and 40 females). The prevalences of factor V Leiden (P = 0.174) and PRT G20210A (P = 0.397) were not different between patients and controls, thereby giving no support to an association of either single-point mutation with SCD. However, an increased prevalence of the MTHFR 677 T/T genotype was seen among patients (8/87) compared to controls (4/105), but this was not statistically significant (P = 0.217; OR = 2.56). This suggested a low impact of inherited hypercoagulability risk factors in the pathogenesis of SCD and/or its complications.

اللغة الأصليةEnglish
الصفحات (من إلى)307-309
عدد الصفحات3
دوريةAmerican Journal of Hematology
مستوى الصوت76
رقم الإصدار3
المعرِّفات الرقمية للأشياء
حالة النشرPublished - يوليو 2004
منشور خارجيًانعم

ASJC Scopus subject areas

  • ???subjectarea.asjc.2700.2720???

بصمة

أدرس بدقة موضوعات البحث “Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا