TY - JOUR
T1 - Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
AU - Global Andrology Forum
AU - Cannarella, Rossella
AU - Shah, Rupin
AU - Abo-Almagd Abdel-Meguid Hamoda, Taha
AU - Boitrelle, Florence
AU - Saleh, Ramadan
AU - Gul, Murat
AU - Rambhatla, Amarnath
AU - Kavoussi, Parviz
AU - Toprak, Tuncay
AU - Harraz, Ahmed M.
AU - Ko, Edmund
AU - Çeker, Gökhan
AU - Durairajanayagam, Damayanthi
AU - Alkahidi, Noora
AU - Kuroda, Shinnosuke
AU - Crafa, Andrea
AU - Henkel, Ralf
AU - Salvio, Gianmaria
AU - Hazir, Berk
AU - Darbandi, Mahsa
AU - Bendayan, Marion
AU - Darbandi, Sara
AU - Falcone, Marco
AU - Garrido, Nicolas
AU - Kosgi, Raghavender
AU - Kaiyal, Raneen Sawaid
AU - Karna, Keshab
AU - Ho Vinh Phuoc, Nguyen
AU - Birowo, Ponco
AU - Colpi, Giovanni M.
AU - de la Rosette, Jean
AU - Pinggera, Germar Michael
AU - Nguyen, Quang
AU - Zini, Armand
AU - Zohdy, Wael
AU - Singh, Rajender
AU - Saini, Pallavi
AU - Glina, Sidney
AU - Lin, Haocheng
AU - Mostafa, Taymour
AU - Rojas-Cruz, Cesar
AU - Arafa, Mohamed
AU - Calogero, Aldo E.
AU - Dimitriadis, Fotios
AU - Kothari, Priyank
AU - Karthikeyan, Vilvapathy Senguttuvan
AU - Okada, Keisuke
AU - Chiba, Koji
AU - Kadıoglu, Ates
AU - Al-Marhoon, Mohamed S.
N1 - Publisher Copyright:
© 2023 World J Mens Healt. All rights reserved.
Copyright © 2023 Korean Society for Sexual Medicine and Andrology.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - PURPOSE: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles.MATERIALS AND METHODS: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies).RESULTS: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864.CONCLUSIONS: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.
AB - PURPOSE: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles.MATERIALS AND METHODS: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies).RESULTS: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864.CONCLUSIONS: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.
KW - Controlled before-after studies
KW - Infertility, male
KW - Meta-analysis
KW - Varicocele
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UR - http://www.scopus.com/inward/citedby.url?scp=85175731583&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/85aa3293-b84c-3f07-88e4-453304114f6d/
U2 - 10.5534/wjmh.230034
DO - 10.5534/wjmh.230034
M3 - Article
C2 - 37382284
AN - SCOPUS:85175731583
SN - 2287-4208
VL - 42
SP - 92
EP - 132
JO - World Journal of Men?s Health
JF - World Journal of Men?s Health
IS - 1
ER -
