Current views on the population structure of Plasmodium falciparum: Implications for control

Hamza A. Babiker*, David Walliker

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

112 الاقتباسات (SciVal)


In recent years there has been a considerable debate on the population genetic structure of malaria parasites. Work on this subject has been revolutionized by the advent of the polymerase chain reaction (PCR) technique, which has made it feasible to study the genetic diversity of parasites in small samples of infected blood, allowing extensive surveys of natural parasite populations to be made. In addition, the technique can be applied to the mosquito stages of the malaria parasite, allowing direct assessments to be made of the frequency of crossing between parasite clones in Nature. Studies on Plasmodium falciparum in a wide range of malaria endemic regions are now revealing the relationship between parasite population structure and malaria epidemiology. In this article, Hamza Babiker and David Walliker review recent work in this field, and discuss how such knowledge might be used to advise on the future deployment of control measures such as antimalarial drugs and possible malaria vaccines.

اللغة الأصليةEnglish
الصفحات (من إلى)262-267
عدد الصفحات6
دوريةParasitology Today
مستوى الصوت13
رقم الإصدار7
المعرِّفات الرقمية للأشياء
حالة النشرPublished - يوليو 1997
منشور خارجيًانعم

ASJC Scopus subject areas

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