COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

John McDonnell; Kimberley Cousins; M. Elizabeth M. Younger; Adam Lane; Hassan Abolhassani; Roshini S. Abraham; Salem Al-Tamemi; Juan Carlos Aldave-Becerra; Eman Hesham Al-Faris; Alberto Alfaro-Murillo; Suzan A. AlKhater; Nouf Alsaati; Alexa Michelle Altman Doss; Melissa Anderson; Ernestina Angarola; Barbara Ariue; Danielle E. Arnold; Amal H. Assa'ad; Caner Aytekin; Meaghan Bank; Jenna R.E. Bergerson; Jack Bleesing; John Boesing; Carolina Bouso; Nicholas Brodszki; Diana Cabanillas; Carol Cady; Meghan A. Callahan; Roberta Caorsi; Javier Carbone; Maria Carrabba; Riccardo Castagnoli; Jason R. Catanzaro; Samantha Chan; Sharat Chandra; Hugo Chapdelaine; Zahra Chavoshzadeh; Hey Jin Chong; Lori Connors; Filippo Consonni; Oscar Correa-Jimenez; Charlotte Cunningham-Rundles; Katherine D'Astous-Gauthier; Ottavia Maria Delmonte; Yesim Yilmaz Demirdag; Deepti R. Deshpande; Natalie M. Diaz-Cabrera; Victoria R. Dimitriades; Rasha El-Owaidy; Gehad ElGhazali; Suleiman Al-Hammadi; Giovanna Fabio; Astrid Schellnast Faure; Jin Feng; James M. Fernandez; Lauren Fill; Guacira R. Franco; Robert W. Frenck; Ramsay L. Fuleihan; Giuliana Giardino; Jessica Galant-Swafford; Eleonora Gambineri; Elizabeth K. Garabedian; Ashley V. Geerlinks; Ekaterini Goudouris; Octavio Grecco; Qiang Pan-Hammarström; Hedieh Haji Khodaverdi Khani; Lennart Hammarström; Nicholas L. Hartog; Jennifer Heimall; Gabriela Hernandez-Molina; Caroline C. Horner; Robert W. Hostoffer; Nataliya Hristova; Kuang Chih Hsiao; Gabriela Ivankovich-Escoto; Faris Jaber; Maaz Jalil; Mahnaz Jamee; Tiffany Jean; Stephanie Jeong; Devi Jhaveri; Michael B. Jordan; Avni Y. Joshi; Amanpreet Kalkat; Henry J. Kanarek; Erinn S. Kellner; Amer Khojah; Ruby Khoury; Cristina M. Kokron; Ashish Kumar; Kelsey Lecerf; Heather K. Lehman; Jennifer W. Leiding; Harry Lesmana; Xin Rong Lim; Joao Pedro Lopes; Ana Laura López; Lucia Tarquini; Ingrid S. Lundgren; Julieann Magnusson; Ana Karolina B.B. Marinho; Gian Luigi Marseglia; Giulia M. Martone; Annamaria G. Mechtler; Leonardo Mendonca; Joshua D. Milner; Peter J. Mustillo; Asal Gharib Naderi; Samuele Naviglio; Jeremy Nell; Hana B. Niebur; Luigi Notarangelo; Matias Oleastro; María Claudia Ortega-López; Neil R. Patel; Gordana Petrovic; Claudio Pignata; Oscar Porras; Benjamin T. Prince; Jennifer M. Puck; Nashmia Qamar; Marco Rabusin; Nikita Raje; Lorena Regairaz; Kimberly A. Risma; Elizabeth H. Ristagno; John Routes; Persio Roxo-Junior; Negin Salemi; Christopher Scalchunes; Susan J. Schuval; Suranjith L. Seneviratne; Ashwin Shankar; Roya Sherkat; Junghee Jenny Shin; Abeer Siddiqi; Sara Signa; Ali Sobh; Fabiana Mascarenhas Souza Lima; Kristen K. Stenehjem; Jonathan S. Tam; Monica Tang; Myrthes Toledo Barros; James Verbsky; Eleni Vergadi; Dayne H. Voelker; Stefano Volpi; Luke A. Wall; Christine Wang; Kelli W. Williams; Eveline Y. Wu; Shan Shan Wu; Jessie J. Zhou; Alexandria Cook; Kathleen E. Sullivan; Rebecca Marsh

doi:10.1007/s10875-023-01613-5

COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

John McDonnell, Kimberley Cousins, M. Elizabeth M. Younger, Adam Lane, Hassan Abolhassani, Roshini S. Abraham, Salem Al-Tamemi, Juan Carlos Aldave-Becerra, Eman Hesham Al-Faris, Alberto Alfaro-Murillo, Suzan A. AlKhater, Nouf Alsaati, Alexa Michelle Altman Doss, Melissa Anderson, Ernestina Angarola, Barbara Ariue, Danielle E. Arnold, Amal H. Assa'ad, Caner Aytekin, Meaghan BankJenna R.E. Bergerson, Jack Bleesing, John Boesing, Carolina Bouso, Nicholas Brodszki, Diana Cabanillas, Carol Cady, Meghan A. Callahan, Roberta Caorsi, Javier Carbone, Maria Carrabba, Riccardo Castagnoli, Jason R. Catanzaro, Samantha Chan, Sharat Chandra, Hugo Chapdelaine, Zahra Chavoshzadeh, Hey Jin Chong, Lori Connors, Filippo Consonni, Oscar Correa-Jimenez, Charlotte Cunningham-Rundles, Katherine D'Astous-Gauthier, Ottavia Maria Delmonte, Yesim Yilmaz Demirdag, Deepti R. Deshpande, Natalie M. Diaz-Cabrera, Victoria R. Dimitriades, Rasha El-Owaidy, Gehad ElGhazali, Suleiman Al-Hammadi, Giovanna Fabio, Astrid Schellnast Faure, Jin Feng, James M. Fernandez, Lauren Fill, Guacira R. Franco, Robert W. Frenck, Ramsay L. Fuleihan, Giuliana Giardino, Jessica Galant-Swafford, Eleonora Gambineri, Elizabeth K. Garabedian, Ashley V. Geerlinks, Ekaterini Goudouris, Octavio Grecco, Qiang Pan-Hammarström, Hedieh Haji Khodaverdi Khani, Lennart Hammarström, Nicholas L. Hartog, Jennifer Heimall, Gabriela Hernandez-Molina, Caroline C. Horner, Robert W. Hostoffer, Nataliya Hristova, Kuang Chih Hsiao, Gabriela Ivankovich-Escoto, Faris Jaber, Maaz Jalil, Mahnaz Jamee, Tiffany Jean, Stephanie Jeong, Devi Jhaveri, Michael B. Jordan, Avni Y. Joshi, Amanpreet Kalkat, Henry J. Kanarek, Erinn S. Kellner, Amer Khojah, Ruby Khoury, Cristina M. Kokron, Ashish Kumar, Kelsey Lecerf, Heather K. Lehman, Jennifer W. Leiding, Harry Lesmana, Xin Rong Lim, Joao Pedro Lopes, Ana Laura López, Lucia Tarquini, Ingrid S. Lundgren, Julieann Magnusson, Ana Karolina B.B. Marinho, Gian Luigi Marseglia, Giulia M. Martone, Annamaria G. Mechtler, Leonardo Mendonca, Joshua D. Milner, Peter J. Mustillo, Asal Gharib Naderi, Samuele Naviglio, Jeremy Nell, Hana B. Niebur, Luigi Notarangelo, Matias Oleastro, María Claudia Ortega-López, Neil R. Patel, Gordana Petrovic, Claudio Pignata, Oscar Porras, Benjamin T. Prince, Jennifer M. Puck, Nashmia Qamar, Marco Rabusin, Nikita Raje, Lorena Regairaz, Kimberly A. Risma, Elizabeth H. Ristagno, John Routes, Persio Roxo-Junior, Negin Salemi, Christopher Scalchunes, Susan J. Schuval, Suranjith L. Seneviratne, Ashwin Shankar, Roya Sherkat, Junghee Jenny Shin, Abeer Siddiqi, Sara Signa, Ali Sobh, Fabiana Mascarenhas Souza Lima, Kristen K. Stenehjem, Jonathan S. Tam, Monica Tang, Myrthes Toledo Barros, James Verbsky, Eleni Vergadi, Dayne H. Voelker, Stefano Volpi, Luke A. Wall, Christine Wang, Kelli W. Williams, Eveline Y. Wu, Shan Shan Wu, Jessie J. Zhou, Alexandria Cook, Kathleen E. Sullivan, Rebecca Marsh

Child Health

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

ملخص

BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI.

OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI.

METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022.

RESULTS: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission.

CONCLUSION: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.

اللغة الأصلية	English
الصفحات (من إلى)	86
عدد الصفحات	1
دورية	Journal of Clinical Immunology
مستوى الصوت	44
رقم الإصدار	4
المعرِّفات الرقمية للأشياء	https://doi.org/10.1007/s10875-023-01613-5
حالة النشر	Published - أبريل 5 2024

ASJC Scopus subject areas

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???subjectarea.asjc.2400.2403???

أهداف الأمم المتحدة للتنمية المستدامة

يساهم هذا المخرج في تحقيق أهداف الأمم المتحدة للتنمية المستدامة التالية (SDGs)

الوصول إلى المستند

10.1007/s10875-023-01613-5

الملفات والروابط الأخرى

قم بذكر هذا

McDonnell, J., Cousins, K., Younger, M. E. M., Lane, A., Abolhassani, H., Abraham, R. S., Al-Tamemi, S., Aldave-Becerra, J. C., Al-Faris, E. H., Alfaro-Murillo, A., AlKhater, S. A., Alsaati, N., Doss, A. M. A., Anderson, M., Angarola, E., Ariue, B., Arnold, D. E., Assa'ad, A. H., Aytekin, C., ... Marsh, R. (2024). COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report. Journal of Clinical Immunology, 44(4), 86. https://doi.org/10.1007/s10875-023-01613-5

COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report. / McDonnell, John; Cousins, Kimberley; Younger, M. Elizabeth M. وآخرون.
في: Journal of Clinical Immunology, المجلد 44, رقم 4, ٠٥.٠٤.٢٠٢٤, صفحة 86.

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

McDonnell, J, Cousins, K, Younger, MEM, Lane, A, Abolhassani, H, Abraham, RS, Al-Tamemi, S, Aldave-Becerra, JC, Al-Faris, EH, Alfaro-Murillo, A, AlKhater, SA, Alsaati, N, Doss, AMA, Anderson, M, Angarola, E, Ariue, B, Arnold, DE, Assa'ad, AH, Aytekin, C, Bank, M, Bergerson, JRE, Bleesing, J, Boesing, J, Bouso, C, Brodszki, N, Cabanillas, D, Cady, C, Callahan, MA, Caorsi, R, Carbone, J, Carrabba, M, Castagnoli, R, Catanzaro, JR, Chan, S, Chandra, S, Chapdelaine, H, Chavoshzadeh, Z, Chong, HJ, Connors, L, Consonni, F, Correa-Jimenez, O, Cunningham-Rundles, C, D'Astous-Gauthier, K, Delmonte, OM, Demirdag, YY, Deshpande, DR, Diaz-Cabrera, NM, Dimitriades, VR, El-Owaidy, R, ElGhazali, G, Al-Hammadi, S, Fabio, G, Faure, AS, Feng, J, Fernandez, JM, Fill, L, Franco, GR, Frenck, RW, Fuleihan, RL, Giardino, G, Galant-Swafford, J, Gambineri, E, Garabedian, EK, Geerlinks, AV, Goudouris, E, Grecco, O, Pan-Hammarström, Q, Khani, HHK, Hammarström, L, Hartog, NL, Heimall, J, Hernandez-Molina, G, Horner, CC, Hostoffer, RW, Hristova, N, Hsiao, KC, Ivankovich-Escoto, G, Jaber, F, Jalil, M, Jamee, M, Jean, T, Jeong, S, Jhaveri, D, Jordan, MB, Joshi, AY, Kalkat, A, Kanarek, HJ, Kellner, ES, Khojah, A, Khoury, R, Kokron, CM, Kumar, A, Lecerf, K, Lehman, HK, Leiding, JW, Lesmana, H, Lim, XR, Lopes, JP, López, AL, Tarquini, L, Lundgren, IS, Magnusson, J, Marinho, AKBB, Marseglia, GL, Martone, GM, Mechtler, AG, Mendonca, L, Milner, JD, Mustillo, PJ, Naderi, AG, Naviglio, S, Nell, J, Niebur, HB, Notarangelo, L, Oleastro, M, Ortega-López, MC, Patel, NR, Petrovic, G, Pignata, C, Porras, O, Prince, BT, Puck, JM, Qamar, N, Rabusin, M, Raje, N, Regairaz, L, Risma, KA, Ristagno, EH, Routes, J, Roxo-Junior, P, Salemi, N, Scalchunes, C, Schuval, SJ, Seneviratne, SL, Shankar, A, Sherkat, R, Shin, JJ, Siddiqi, A, Signa, S, Sobh, A, Lima, FMS, Stenehjem, KK, Tam, JS, Tang, M, Barros, MT, Verbsky, J, Vergadi, E, Voelker, DH, Volpi, S, Wall, LA, Wang, C, Williams, KW, Wu, EY, Wu, SS, Zhou, JJ, Cook, A, Sullivan, KE & Marsh, R 2024, 'COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report', Journal of Clinical Immunology, المجلد 44, رقم 4, الصفحات 86. https://doi.org/10.1007/s10875-023-01613-5

@article{2a0042e35fe14d0993a04d5de0d368b2,

title = "COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report",

abstract = "BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI.OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI.METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022.RESULTS: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission.CONCLUSION: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.",

keywords = "Immunization, Immunodeficiency, Outcomes, Viruses: respiratory diseases, COVID-19/epidemiology, Humans, Vaccination, Critical Care, COVID-19 Vaccines/adverse effects, Hospitalization",

author = "John McDonnell and Kimberley Cousins and Younger, {M. Elizabeth M.} and Adam Lane and Hassan Abolhassani and Abraham, {Roshini S.} and Salem Al-Tamemi and Aldave-Becerra, {Juan Carlos} and Al-Faris, {Eman Hesham} and Alberto Alfaro-Murillo and AlKhater, {Suzan A.} and Nouf Alsaati and Doss, {Alexa Michelle Altman} and Melissa Anderson and Ernestina Angarola and Barbara Ariue and Arnold, {Danielle E.} and Assa'ad, {Amal H.} and Caner Aytekin and Meaghan Bank and Bergerson, {Jenna R.E.} and Jack Bleesing and John Boesing and Carolina Bouso and Nicholas Brodszki and Diana Cabanillas and Carol Cady and Callahan, {Meghan A.} and Roberta Caorsi and Javier Carbone and Maria Carrabba and Riccardo Castagnoli and Catanzaro, {Jason R.} and Samantha Chan and Sharat Chandra and Hugo Chapdelaine and Zahra Chavoshzadeh and Chong, {Hey Jin} and Lori Connors and Filippo Consonni and Oscar Correa-Jimenez and Charlotte Cunningham-Rundles and Katherine D'Astous-Gauthier and Delmonte, {Ottavia Maria} and Demirdag, {Yesim Yilmaz} and Deshpande, {Deepti R.} and Diaz-Cabrera, {Natalie M.} and Dimitriades, {Victoria R.} and Rasha El-Owaidy and Gehad ElGhazali and Suleiman Al-Hammadi and Giovanna Fabio and Faure, {Astrid Schellnast} and Jin Feng and Fernandez, {James M.} and Lauren Fill and Franco, {Guacira R.} and Frenck, {Robert W.} and Fuleihan, {Ramsay L.} and Giuliana Giardino and Jessica Galant-Swafford and Eleonora Gambineri and Garabedian, {Elizabeth K.} and Geerlinks, {Ashley V.} and Ekaterini Goudouris and Octavio Grecco and Qiang Pan-Hammarstr{\"o}m and Khani, {Hedieh Haji Khodaverdi} and Lennart Hammarstr{\"o}m and Hartog, {Nicholas L.} and Jennifer Heimall and Gabriela Hernandez-Molina and Horner, {Caroline C.} and Hostoffer, {Robert W.} and Nataliya Hristova and Hsiao, {Kuang Chih} and Gabriela Ivankovich-Escoto and Faris Jaber and Maaz Jalil and Mahnaz Jamee and Tiffany Jean and Stephanie Jeong and Devi Jhaveri and Jordan, {Michael B.} and Joshi, {Avni Y.} and Amanpreet Kalkat and Kanarek, {Henry J.} and Kellner, {Erinn S.} and Amer Khojah and Ruby Khoury and Kokron, {Cristina M.} and Ashish Kumar and Kelsey Lecerf and Lehman, {Heather K.} and Leiding, {Jennifer W.} and Harry Lesmana and Lim, {Xin Rong} and Lopes, {Joao Pedro} and L{\'o}pez, {Ana Laura} and Lucia Tarquini and Lundgren, {Ingrid S.} and Julieann Magnusson and Marinho, {Ana Karolina B.B.} and Marseglia, {Gian Luigi} and Martone, {Giulia M.} and Mechtler, {Annamaria G.} and Leonardo Mendonca and Milner, {Joshua D.} and Mustillo, {Peter J.} and Naderi, {Asal Gharib} and Samuele Naviglio and Jeremy Nell and Niebur, {Hana B.} and Luigi Notarangelo and Matias Oleastro and Ortega-L{\'o}pez, {Mar{\'i}a Claudia} and Patel, {Neil R.} and Gordana Petrovic and Claudio Pignata and Oscar Porras and Prince, {Benjamin T.} and Puck, {Jennifer M.} and Nashmia Qamar and Marco Rabusin and Nikita Raje and Lorena Regairaz and Risma, {Kimberly A.} and Ristagno, {Elizabeth H.} and John Routes and Persio Roxo-Junior and Negin Salemi and Christopher Scalchunes and Schuval, {Susan J.} and Seneviratne, {Suranjith L.} and Ashwin Shankar and Roya Sherkat and Shin, {Junghee Jenny} and Abeer Siddiqi and Sara Signa and Ali Sobh and Lima, {Fabiana Mascarenhas Souza} and Stenehjem, {Kristen K.} and Tam, {Jonathan S.} and Monica Tang and Barros, {Myrthes Toledo} and James Verbsky and Eleni Vergadi and Voelker, {Dayne H.} and Stefano Volpi and Wall, {Luke A.} and Christine Wang and Williams, {Kelli W.} and Wu, {Eveline Y.} and Wu, {Shan Shan} and Zhou, {Jessie J.} and Alexandria Cook and Sullivan, {Kathleen E.} and Rebecca Marsh",

note = "Publisher Copyright: {\textcopyright} 2024. The Author(s).",

year = "2024",

month = apr,

day = "5",

doi = "10.1007/s10875-023-01613-5",

language = "English",

volume = "44",

pages = "86",

journal = "Journal of Clinical Immunology",

issn = "0271-9142",

publisher = "Springer New York",

number = "4",

}

TY - JOUR

T1 - COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19

T2 - a USIDNET Report

AU - McDonnell, John

AU - Cousins, Kimberley

AU - Younger, M. Elizabeth M.

AU - Lane, Adam

AU - Abolhassani, Hassan

AU - Abraham, Roshini S.

AU - Al-Tamemi, Salem

AU - Aldave-Becerra, Juan Carlos

AU - Al-Faris, Eman Hesham

AU - Alfaro-Murillo, Alberto

AU - AlKhater, Suzan A.

AU - Alsaati, Nouf

AU - Doss, Alexa Michelle Altman

AU - Anderson, Melissa

AU - Angarola, Ernestina

AU - Ariue, Barbara

AU - Arnold, Danielle E.

AU - Assa'ad, Amal H.

AU - Aytekin, Caner

AU - Bank, Meaghan

AU - Bergerson, Jenna R.E.

AU - Bleesing, Jack

AU - Boesing, John

AU - Bouso, Carolina

AU - Brodszki, Nicholas

AU - Cabanillas, Diana

AU - Cady, Carol

AU - Callahan, Meghan A.

AU - Caorsi, Roberta

AU - Carbone, Javier

AU - Carrabba, Maria

AU - Castagnoli, Riccardo

AU - Catanzaro, Jason R.

AU - Chan, Samantha

AU - Chandra, Sharat

AU - Chapdelaine, Hugo

AU - Chavoshzadeh, Zahra

AU - Chong, Hey Jin

AU - Connors, Lori

AU - Consonni, Filippo

AU - Correa-Jimenez, Oscar

AU - Cunningham-Rundles, Charlotte

AU - D'Astous-Gauthier, Katherine

AU - Delmonte, Ottavia Maria

AU - Demirdag, Yesim Yilmaz

AU - Deshpande, Deepti R.

AU - Diaz-Cabrera, Natalie M.

AU - Dimitriades, Victoria R.

AU - El-Owaidy, Rasha

AU - ElGhazali, Gehad

AU - Al-Hammadi, Suleiman

AU - Fabio, Giovanna

AU - Faure, Astrid Schellnast

AU - Feng, Jin

AU - Fernandez, James M.

AU - Fill, Lauren

AU - Franco, Guacira R.

AU - Frenck, Robert W.

AU - Fuleihan, Ramsay L.

AU - Giardino, Giuliana

AU - Galant-Swafford, Jessica

AU - Gambineri, Eleonora

AU - Garabedian, Elizabeth K.

AU - Geerlinks, Ashley V.

AU - Goudouris, Ekaterini

AU - Grecco, Octavio

AU - Pan-Hammarström, Qiang

AU - Khani, Hedieh Haji Khodaverdi

AU - Hammarström, Lennart

AU - Hartog, Nicholas L.

AU - Heimall, Jennifer

AU - Hernandez-Molina, Gabriela

AU - Horner, Caroline C.

AU - Hostoffer, Robert W.

AU - Hristova, Nataliya

AU - Hsiao, Kuang Chih

AU - Ivankovich-Escoto, Gabriela

AU - Jaber, Faris

AU - Jalil, Maaz

AU - Jamee, Mahnaz

AU - Jean, Tiffany

AU - Jeong, Stephanie

AU - Jhaveri, Devi

AU - Jordan, Michael B.

AU - Joshi, Avni Y.

AU - Kalkat, Amanpreet

AU - Kanarek, Henry J.

AU - Kellner, Erinn S.

AU - Khojah, Amer

AU - Khoury, Ruby

AU - Kokron, Cristina M.

AU - Kumar, Ashish

AU - Lecerf, Kelsey

AU - Lehman, Heather K.

AU - Leiding, Jennifer W.

AU - Lesmana, Harry

AU - Lim, Xin Rong

AU - Lopes, Joao Pedro

AU - López, Ana Laura

AU - Tarquini, Lucia

AU - Lundgren, Ingrid S.

AU - Magnusson, Julieann

AU - Marinho, Ana Karolina B.B.

AU - Marseglia, Gian Luigi

AU - Martone, Giulia M.

AU - Mechtler, Annamaria G.

AU - Mendonca, Leonardo

AU - Milner, Joshua D.

AU - Mustillo, Peter J.

AU - Naderi, Asal Gharib

AU - Naviglio, Samuele

AU - Nell, Jeremy

AU - Niebur, Hana B.

AU - Notarangelo, Luigi

AU - Oleastro, Matias

AU - Ortega-López, María Claudia

AU - Patel, Neil R.

AU - Petrovic, Gordana

AU - Pignata, Claudio

AU - Porras, Oscar

AU - Prince, Benjamin T.

AU - Puck, Jennifer M.

AU - Qamar, Nashmia

AU - Rabusin, Marco

AU - Raje, Nikita

AU - Regairaz, Lorena

AU - Risma, Kimberly A.

AU - Ristagno, Elizabeth H.

AU - Routes, John

AU - Roxo-Junior, Persio

AU - Salemi, Negin

AU - Scalchunes, Christopher

AU - Schuval, Susan J.

AU - Seneviratne, Suranjith L.

AU - Shankar, Ashwin

AU - Sherkat, Roya

AU - Shin, Junghee Jenny

AU - Siddiqi, Abeer

AU - Signa, Sara

AU - Sobh, Ali

AU - Lima, Fabiana Mascarenhas Souza

AU - Stenehjem, Kristen K.

AU - Tam, Jonathan S.

AU - Tang, Monica

AU - Barros, Myrthes Toledo

AU - Verbsky, James

AU - Vergadi, Eleni

AU - Voelker, Dayne H.

AU - Volpi, Stefano

AU - Wall, Luke A.

AU - Wang, Christine

AU - Williams, Kelli W.

AU - Wu, Eveline Y.

AU - Wu, Shan Shan

AU - Zhou, Jessie J.

AU - Cook, Alexandria

AU - Sullivan, Kathleen E.

AU - Marsh, Rebecca

PY - 2024/4/5

Y1 - 2024/4/5

N2 - BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI.OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI.METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022.RESULTS: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission.CONCLUSION: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.

AB - BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI.OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI.METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022.RESULTS: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission.CONCLUSION: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.

KW - Immunization

KW - Immunodeficiency

KW - Outcomes

KW - Viruses: respiratory diseases

KW - COVID-19/epidemiology

KW - Humans

KW - Vaccination

KW - Critical Care

KW - COVID-19 Vaccines/adverse effects

KW - Hospitalization

UR - http://www.scopus.com/inward/record.url?scp=85190084914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85190084914&partnerID=8YFLogxK

U2 - 10.1007/s10875-023-01613-5

DO - 10.1007/s10875-023-01613-5

M3 - Article

C2 - 38578389

AN - SCOPUS:85190084914

SN - 0271-9142

VL - 44

SP - 86

JO - Journal of Clinical Immunology

JF - Journal of Clinical Immunology

IS - 4

ER -