TY - JOUR
T1 - Clinical profile of myasthenia gravis in the Sultanate of Oman
AU - Jacob, Poovathoor C.
AU - Tharakan, John T.
AU - Chand, Pratap R.
AU - Koul, Roshan L.
AU - Chacko, Alexander P.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Objective: Clinical study and follow up of myasthenia gravis patients in Oman. Methods: Follow up of 50 consecutive myasthenia gravis patients referred to the Sultan Qaboos University Hospital, Oman for a median period of 3 years from 1997 to 2000. We based the diagnosis on the clinical picture, repetitive nerve stimulation tests and edrophonium test. We performed a computerized tomography scan of the chest and anti-acetylcholine receptor antibodies. We reviewed the results of immuno modulatory treatment including thymectomy and compared these with other studies. Results: Of 50 patients, 6 had purely ocular myasthenia. Of the 44 with generalized myasthenia, 28 had bulbar involvement and 12 required ventilatory support. Eight out of 29 thymectomized patients had drug free remission after 2 years. There was worsening of myasthenic symptoms in only one out of 8 pregnancies and deliveries. Conclusions: Bulbar and ventilatory involvement are more common in our series as compared with western data. Pregnancy and delivery were well tolerated.
AB - Objective: Clinical study and follow up of myasthenia gravis patients in Oman. Methods: Follow up of 50 consecutive myasthenia gravis patients referred to the Sultan Qaboos University Hospital, Oman for a median period of 3 years from 1997 to 2000. We based the diagnosis on the clinical picture, repetitive nerve stimulation tests and edrophonium test. We performed a computerized tomography scan of the chest and anti-acetylcholine receptor antibodies. We reviewed the results of immuno modulatory treatment including thymectomy and compared these with other studies. Results: Of 50 patients, 6 had purely ocular myasthenia. Of the 44 with generalized myasthenia, 28 had bulbar involvement and 12 required ventilatory support. Eight out of 29 thymectomized patients had drug free remission after 2 years. There was worsening of myasthenic symptoms in only one out of 8 pregnancies and deliveries. Conclusions: Bulbar and ventilatory involvement are more common in our series as compared with western data. Pregnancy and delivery were well tolerated.
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M3 - Article
C2 - 12883613
AN - SCOPUS:0042567391
SN - 0379-5284
VL - 24
SP - 774
EP - 775
JO - Saudi Medical Journal
JF - Saudi Medical Journal
IS - 7
ER -