Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope; Oladimeji T. Audu; Yoshio Takeda; Lu Zeng; Guoen Shi; Hiroko Shimada; Jerry L. McLaughlin

doi:10.1021/np9601566

Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope, Oladimeji T. Audu, Yoshio Takeda, Lu Zeng, Guoen Shi, Hiroko Shimada, Jerry L. McLaughlin^*

^*المؤلف المقابل لهذا العمل

Chemistry

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

52 اقتباسات (Scopus)

ملخص

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED₅₀ 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED₅₀ 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

اللغة الأصلية	English
الصفحات (من إلى)	301-303
عدد الصفحات	3
دورية	Journal of Natural Products
مستوى الصوت	59
رقم الإصدار	3
المعرِّفات الرقمية للأشياء	https://doi.org/10.1021/np9601566
حالة النشر	Published - مارس 1996

ASJC Scopus subject areas

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أهداف الأمم المتحدة للتنمية المستدامة

يساهم هذا المخرج في تحقيق أهداف الأمم المتحدة للتنمية المستدامة التالية (SDGs)

الوصول إلى المستند

10.1021/np9601566

الملفات والروابط الأخرى

قم بذكر هذا

@article{e3d2c0ec21dd47ffb188292f6bd7afe3,

title = "Bioactive ent-kaurene diterpenoids from Annona senegalensis",

abstract = "Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.",

author = "Fatope, {Majekodunmi O.} and Audu, {Oladimeji T.} and Yoshio Takeda and Lu Zeng and Guoen Shi and Hiroko Shimada and McLaughlin, {Jerry L.}",

year = "1996",

month = mar,

doi = "10.1021/np9601566",

language = "English",

volume = "59",

pages = "301--303",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "3",

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TY - JOUR

T1 - Bioactive ent-kaurene diterpenoids from Annona senegalensis

AU - Fatope, Majekodunmi O.

AU - Audu, Oladimeji T.

AU - Takeda, Yoshio

AU - Zeng, Lu

AU - Shi, Guoen

AU - Shimada, Hiroko

AU - McLaughlin, Jerry L.

PY - 1996/3

Y1 - 1996/3

N2 - Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

AB - Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

UR - http://www.scopus.com/inward/record.url?scp=0030012201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030012201&partnerID=8YFLogxK

U2 - 10.1021/np9601566

DO - 10.1021/np9601566

M3 - Article

C2 - 8882434

AN - SCOPUS:0030012201

SN - 0163-3864

VL - 59

SP - 301

EP - 303

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 3

ER -

Bioactive ent-kaurene diterpenoids from Annona senegalensis

ملخص

ASJC Scopus subject areas

أهداف الأمم المتحدة للتنمية المستدامة

الوصول إلى المستند

الملفات والروابط الأخرى

بصمة

قم بذكر هذا