TY - JOUR
T1 - Bioactive Constituents of Pulicaria jaubertii
T2 - A promising antihypertensive activity
AU - El-Ghaly, El Sayed M.
AU - Shaheen, Usama
AU - Ragab, Ehab
AU - El-Hila, Atef Ahmed
AU - Abd-Allah, Mohamed Raafat
PY - 2016
Y1 - 2016
N2 - Objective: Phytochemical investigation and evaluation of antihypertensive activity of the alcoholic extract of Pulicaria jaubertii aerial parts. Material and Methods: The chloroform and ethyl acetate fractions were chromatographed on silica gel and sephadex LH 20 to afford six compounds. Their structures were elucidated on the bases of extensive NMR (1H, 13C, DEPT, COSY, HSQC, HMBC, NOESY) and MS analysis. The antihypertensive activity of the alcoholic extract was evaluated against L-NAME-induced hypertensive rats. Results: One new monoterpene glucoside; (2R, 4S)-p-menth-1-ene-2-O-b-D-glucopyranoside [1] along with five known compounds; thymoquinol 2-O-b-D-glucopyranoside (zataroside-B) [2], quercetin 7, β-di-Omethylether (rhamnazin) [3], quercetin 7-O-methylether (rhamnetin) [4], quercetin β-O-methylether (isorhamnetin) [5] and stigmasterol 3-Ob-D-glucopyranoside [6] were isolated. The alcoholic extract significantly reduced the elevated SBP and partially restored the diminished nitric oxide metabolites. Conclusion: Compound [1] is a new and compounds [2-6] are reported for first time from Pulicaria jaubertii. The possible antihypertensive activity of the alcoholic extract may be due to its flavonoids and phenolic contents.
AB - Objective: Phytochemical investigation and evaluation of antihypertensive activity of the alcoholic extract of Pulicaria jaubertii aerial parts. Material and Methods: The chloroform and ethyl acetate fractions were chromatographed on silica gel and sephadex LH 20 to afford six compounds. Their structures were elucidated on the bases of extensive NMR (1H, 13C, DEPT, COSY, HSQC, HMBC, NOESY) and MS analysis. The antihypertensive activity of the alcoholic extract was evaluated against L-NAME-induced hypertensive rats. Results: One new monoterpene glucoside; (2R, 4S)-p-menth-1-ene-2-O-b-D-glucopyranoside [1] along with five known compounds; thymoquinol 2-O-b-D-glucopyranoside (zataroside-B) [2], quercetin 7, β-di-Omethylether (rhamnazin) [3], quercetin 7-O-methylether (rhamnetin) [4], quercetin β-O-methylether (isorhamnetin) [5] and stigmasterol 3-Ob-D-glucopyranoside [6] were isolated. The alcoholic extract significantly reduced the elevated SBP and partially restored the diminished nitric oxide metabolites. Conclusion: Compound [1] is a new and compounds [2-6] are reported for first time from Pulicaria jaubertii. The possible antihypertensive activity of the alcoholic extract may be due to its flavonoids and phenolic contents.
KW - Antihypertensive activity
KW - Flavonoids
KW - Monoterpene glucoside
KW - Nitric oxide
KW - Pulicaria jaubertii
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U2 - 10.5530/pj.2016.1.18
DO - 10.5530/pj.2016.1.18
M3 - Article
AN - SCOPUS:84962258917
SN - 0975-3575
VL - 8
SP - 81
EP - 86
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 1
ER -