TY - JOUR
T1 - Association of the Magnitude of Anti-SARS-CoV-2 Vaccine Side Effects with Sex, Allergy History, Chronic Diseases, Medication Intake, and SARS-CoV-2 Infection
AU - Said, Elias A.
AU - Al-Rubkhi, Afnan
AU - Jaju, Sanjay
AU - Koh, Crystal Y.
AU - Al-Balushi, Mohammed S.
AU - Al-Naamani, Khalid
AU - Al-Sinani, Siham
AU - Al-Busaidi, Juma Z.
AU - Al-Jabri, Ali A.
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/1/20
Y1 - 2024/1/20
N2 - Vaccination provides the best protection against the increasing infections of SARS-CoV-2. The magnitude and type of anti-SARS-CoV-2 vaccine side effects (SEs) depend on parameters that are not fully understood. In this cross-sectional study, the associations between different anti-SARS-CoV-2 vaccine SEs and age, sex, the presence of chronic diseases, medication intake, history of allergies, and infections with SARS-CoV-2 were investigated. Our survey used the Google platform and had 866 participants, contacted through e-mails, social media and chain referral sampling (margin of error ≈ 4.38%, 99% confidence). More than 99% of the participants received the BNT162b2 and ChAdOx1-S vaccines. Being female, having chronic diseases, taking medicines routinely and the presence of a SARS-CoV-2 infection (p < 0.05) were associated with strong SEs after the BNT162b2 vaccine second dose. Having a history of allergies and a female sex (p < 0.01) were associated with strong SEs after the ChAdOx1-S vaccine second dose. Furthermore, the results reveal, for the first time, the associations between having a history of allergies, chronic diseases, medication usage, and SEs of a strong magnitude for the BNT162b2 and ChAdOx1-S vaccines. Additionally, this study supports the association of the female sex and infection with SARS-CoV-2 with an increased potential of developing stronger SEs with certain anti-SARS-CoV-2 vaccines.
AB - Vaccination provides the best protection against the increasing infections of SARS-CoV-2. The magnitude and type of anti-SARS-CoV-2 vaccine side effects (SEs) depend on parameters that are not fully understood. In this cross-sectional study, the associations between different anti-SARS-CoV-2 vaccine SEs and age, sex, the presence of chronic diseases, medication intake, history of allergies, and infections with SARS-CoV-2 were investigated. Our survey used the Google platform and had 866 participants, contacted through e-mails, social media and chain referral sampling (margin of error ≈ 4.38%, 99% confidence). More than 99% of the participants received the BNT162b2 and ChAdOx1-S vaccines. Being female, having chronic diseases, taking medicines routinely and the presence of a SARS-CoV-2 infection (p < 0.05) were associated with strong SEs after the BNT162b2 vaccine second dose. Having a history of allergies and a female sex (p < 0.01) were associated with strong SEs after the ChAdOx1-S vaccine second dose. Furthermore, the results reveal, for the first time, the associations between having a history of allergies, chronic diseases, medication usage, and SEs of a strong magnitude for the BNT162b2 and ChAdOx1-S vaccines. Additionally, this study supports the association of the female sex and infection with SARS-CoV-2 with an increased potential of developing stronger SEs with certain anti-SARS-CoV-2 vaccines.
KW - BNT162b2
KW - ChAdOx1-S
KW - SARS-CoV-2
KW - side effect
KW - vaccine
UR - http://www.scopus.com/inward/record.url?scp=85183187224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85183187224&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/dcf239e6-0ffc-366d-a9dd-79c6db220a89/
U2 - 10.3390/vaccines12010104
DO - 10.3390/vaccines12010104
M3 - Article
C2 - 38276676
AN - SCOPUS:85183187224
SN - 2076-393X
VL - 12
JO - Vaccines
JF - Vaccines
IS - 1
M1 - 104
ER -