Antioxidant and Antiaging Properties of Agar Obtained from Brown Seaweed Laminaria digitata (Hudson) in D-Galactose-Induced Swiss Albino Mice

B. S. Reshma, Thabitha Aavula, Vignesh Narasimman, Saravanan Ramachandran*, Musthafa Mohamed Essa, M. Walid Qoronfleh

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

4 اقتباسات (Scopus)

ملخص

The present paper explores the antioxidant and antiaging properties of agar extracted from Laminaria digitata (L. digitata) on a D-galactose (D-Gal)-induced mouse model. Experimental mice were divided into four groups: group I comprised of control nontreated mice, group II comprised of D-Gal-induced mice, group III mice were treated with extracted agar after D-Gal induction, and group IV mice were given ascorbic acid as a positive control. Antioxidant enzymes and aging marker proteins declined significantly in group II, whereas they were normal in group III and group IV mice. Expressions of interleukin-1β (IL-1β) in D-Gal-induced mice were significantly enhanced in the liver and brain of the experimental mice, which were otherwise normal in agar-treated mice. Also, IL-6 levels were significantly increased in the liver and reversed in the brain of D-gal mice, while it was regularly in the agar-treated mice. The histopathological analysis of D-Gal-induced mice showed spongiosis and tangles in brain cells, increased fat and decreased collagen contents in the skin, and few dilated sinuses in the hepatic cells. The changes were under control in group III and group IV mice, suggesting the protective effects of agar extracted from L. digitata and ascorbic acid.

اللغة الأصليةEnglish
رقم المقال7736378
الصفحات (من إلى)7736378
دوريةEvidence-based Complementary and Alternative Medicine
مستوى الصوت2022
المعرِّفات الرقمية للأشياء
حالة النشرPublished - فبراير 24 2022

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بصمة

أدرس بدقة موضوعات البحث “Antioxidant and Antiaging Properties of Agar Obtained from Brown Seaweed Laminaria digitata (Hudson) in D-Galactose-Induced Swiss Albino Mice'. فهما يشكلان معًا بصمة فريدة.

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