TY - JOUR
T1 - Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity
AU - Muzammil, Aqsa
AU - Waqas, Muhammad
AU - Umar, Ahitsham
AU - Sufyan, Muhammad
AU - Rehman, Abdur
AU - Haider, Ali
AU - Akram, Haseeb
AU - Khan, Seemab Amjad Fateh
AU - Afzal, Muhammad
AU - Wajid, Muhammad
AU - Tahir, Rana Adnan
AU - Sehgal, Sheikh Arslan
N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
PY - 2021
Y1 - 2021
N2 - Aging is an unavoidable process, leading to cell senescence due to physiochemical changes in an organism. Anti-aging remedies have always been of great interest since ancient times. The purpose of anti-aging activities is to increase the life span and the quality of life. Anti-aging activities are primarily involved in the therapies of age-related disorders such as Parkinson's Disease (PD), Alzheimer's Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. These diseases are triggered by multiple factors that are involved in numerous molecular pathways including telomere shortening, NF-κB pathway, adiponectin receptor pathway, insulin, and IGF signaling pathway, AMPK, mTOR, and mitochondria dysfunction. Natural products are known as effective molecules to delay the aging process through influencing metabolic pathways and thus ensure an extended lifespan. These natural compounds are being utilized in drug design and development through computational and high throughput techniques for effective pro-longevity drugs. A comprehensive study on natural compounds demonstrating their anti-aging activities along with databases of natural products for drug designing was executed and summarized in this review article.
AB - Aging is an unavoidable process, leading to cell senescence due to physiochemical changes in an organism. Anti-aging remedies have always been of great interest since ancient times. The purpose of anti-aging activities is to increase the life span and the quality of life. Anti-aging activities are primarily involved in the therapies of age-related disorders such as Parkinson's Disease (PD), Alzheimer's Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. These diseases are triggered by multiple factors that are involved in numerous molecular pathways including telomere shortening, NF-κB pathway, adiponectin receptor pathway, insulin, and IGF signaling pathway, AMPK, mTOR, and mitochondria dysfunction. Natural products are known as effective molecules to delay the aging process through influencing metabolic pathways and thus ensure an extended lifespan. These natural compounds are being utilized in drug design and development through computational and high throughput techniques for effective pro-longevity drugs. A comprehensive study on natural compounds demonstrating their anti-aging activities along with databases of natural products for drug designing was executed and summarized in this review article.
KW - Animals
KW - Biological Products/pharmacology
KW - Geroscience
KW - Humans
KW - Longevity/drug effects
KW - Metabolic Networks and Pathways/drug effects
KW - Quality of Life
UR - http://www.scopus.com/inward/record.url?scp=85119967024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85119967024&partnerID=8YFLogxK
U2 - 10.2174/1389557521666210405162006
DO - 10.2174/1389557521666210405162006
M3 - Review article
C2 - 33820505
SN - 1389-5575
VL - 21
SP - 2630
EP - 2656
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 18
ER -