Analysis of fexofenadine in pharmaceutical formulations using tris (1,10‐phenanthroline)–ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device Haider A.

A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical
formulations, using a tris(1,10‐phenanthroline)–ruthenium(II) [Ru(phen)3
2+] peroxydisulphate chemiluminescence (CL) system in
a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and
concentration of reagents used. Under optimumconditions, a linear calibration curve in the range 0.05–5.0 μg/mL was obtained.
The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products
and was found to be free from interference from concomitants usually present in these preparations.