Alloimmunization in patients with sickle cell disease and thalassemia: Experience of a single centre in oman

Salam Alkindi*, Saba AlMahrooqi, Sumaiya AlHinai, Ali AlMarhoobi, Saif Al-Hosni, Shahina Daar, Naglaa Fawaz, Anil Pathare

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

18 اقتباسات (Scopus)


Background: Blood transfusion is an integral part of the supportive care for patients with sickle cell disease (SCD) and thalassaemia. The hazard of red cell alloimmunization however is one of the main complications of this therapy. Objectives: The aim of this study was to evaluate the prevalence of red cell alloimmunization in Omani patients with sickle cell anaemia and thalassemia. Methods: This study included 262 patients whose historical transfusion records were available. One hundred and twenty-nine patients with thalassaemia who were attending the day care unit for regular transfusions and 133 SCD patients admitted at our hospital were included in this study. The Diamed® gel system was used for the screening and identification of atypical antibodies. Results: The rate of alloimmunization in SCD patients was 31.6% (n=42 95%CI 24.87-40.66) whereas in patients with thalassaemia it was 20% (n=26; 95%CI 13.9-27.6). Antibodies to E e C c D K S Fya Kpa Jka and Cw were observed; 85% of the patients were also immunised with Rh and Kell antigens. Considering the two groups together 8 developed nonspecific antibodies and 12 developed more than one antibody. Conclusions: Red cell transfusions were associated with a significant risk of alloimmunization. It is therefore imperative to perform an initial extended red cell phenotyping for both donors and recipients and carefully select ABO Rh and Kell matched donors. The higher incidence of alloimmunization in SCD patients is related to the inherent SCD-specific inflammatory state.

اللغة الأصليةEnglish
رقم المقالe2017013
دوريةMediterranean Journal of Hematology and Infectious Diseases
مستوى الصوت9
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرPublished - 2017

ASJC Scopus subject areas

  • ???subjectarea.asjc.2700.2720???
  • ???subjectarea.asjc.2700.2725???


أدرس بدقة موضوعات البحث “Alloimmunization in patients with sickle cell disease and thalassemia: Experience of a single centre in oman'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا