Age-specific progression of nigrostriatal dysfunction in Parkinson's disease

Raúl De La Fuente-Fernández*, Michael Schulzer, Lisa Kuramoto, Jacquelyn Cragg, Nandhagopal Ramachandiran, Wing L. Au, Edwin Mak, Jess McKenzie, Siobhan McCormick, Vesna Sossi, Thomas J. Ruth, Chong S. Lee, Donald B. Calne, A. Jon Stoessl

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

186 اقتباسات (Scopus)


Objective: To investigate in vivo the impact of age on nigrostriatal dopamine dysfunction in Parkinson's disease (PD). Methods: PD patients (n = 78) and healthy control subjects (n = 35) underwent longitudinal positron emission tomography assessments using 3 presynaptic dopamine markers: (1) [ 11C](±)dihydrotetrabenazine (DTBZ), to estimate the density of the vesicular monoamine transporter type 2; (2) [11C]d-threo- methylphenidate, to estimate the density of the plasma membrane dopamine transporter; and (3) 6-[18F]-fluoro-L-dopa, to estimate the activity of the enzyme dopa-decarboxylase. Results: The study comprised 438 PD scans and 241 control scans (679 scans in total). At symptom onset, the loss of putamen DTBZ binding was substantially greater in younger compared to older PD patients (p = 0.015). Remarkably, however, the rate of progression of DTBZ binding loss was significantly slower in younger patients (p < 0.05). The estimated presymptomatic phase of the disease spanned more than 2 decades in younger patients, compared to 1 decade in older patients. Interpretation: Our results suggest that, compared to older patients, younger PD patients progress more slowly and are able to endure more damage to the dopaminergic system before the first motor symptoms appear. These observations suggest that younger PD patients have more efficient compensatory mechanisms.

اللغة الأصليةEnglish
الصفحات (من إلى)803-810
عدد الصفحات8
دوريةAnnals of Neurology
مستوى الصوت69
رقم الإصدار5
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مايو 2011
منشور خارجيًانعم

ASJC Scopus subject areas

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