A family study in Oman: Large, consanguineous, polygamous Omani Arab pedigrees - A planned model for the study of complex diseases

Objective: To establish a suitable human model for the study of the genetics of complex diseases. Methods: We have selected an Omani Arab population to provide the statistical power required to study the genetics of complex diseases with confidence. This model consists of five multigenerational highly inbred pedigrees, descending from a small number of founders just a few generations ago with environmental homogeneity, restricted geographical distribution, detailed records and well-as-certained and -validated pedigrees. Stringent criteria were adopted for defining the phenotypes of hypertension, diabetes mellitus, dyslipidemias and obesity. The SOLAR genetic software package was used to draw the pedigree structure. Results: Outstand ing statistical power to detect susceptibility loci was obtained. Conclusions: This model represents a large homogeneous human family-based population for the study of genetic and environmental factors contributing to complex diseases.