Validity of different prostate specific markers (total PSA, free PSA, and -2 pro PSA) in the diagnosis of prostate cancer

Prostate cancer is the leading cancer in older men. It is the most common cancer in men in the United States (U.S), with estimated figures of 238,590 new cases of prostate cancer, 29,720 death of prostate cancer, and one sixth of men will be diagnosed with prostate cancer during 2013 as per the American Cancer Society s. (1) Prostate cancer when detected early (organ defined) is potentially curable by radical prostatectomy. Therefore, early detection is important and prostate-specific antigen (PSA) is widely used for this purpose. However, despite the wide use of PSA, its value in screening men particularly asymptomatic is controversial particularly in term of risks and benefits of early detection.