Association between Sleep Pattern in Oman and Cardiometabolic disorders

We propose to carry out a sleep and metabolism case-control association study, investigating the link between obstructive sleep apnea (OSA) and sleep deprivation and metabolic syndrome in Omani population. Sleep is vital for human body to carry normal metabolic process. The rapid socio-economic changes that had occurred in our society in the last decades had made negative impact on people s health. This study is proposed to examine the association between disturbed sleep and the metabolic components of the metabolic syndrome; diabetes mellitus, hypertension, obesity, hyperlipidemia and heart diseases. The high prevalence of the metabolic syndrome in Oman as well as high prevalence of obstructive sleep apnea will provide a sufficient statistical power to conduct this study. The study will be performed in Sultan Qaboos University Hospital (SQUH) targeting patients attending lipid clinic and family physician clinic. Sleep quality will be assessed at SQUH Sleep Laboratory. The medical and technical experience as well as the high quality facilities in SQUH to perform the physiological and biochemical tests would provide a reliable platform to do this study. The funds requested will be sufficient to determine the association between OSA and sleep deprivation and metabolic syndrome with required statistical power.