Understanding the functional discrepancy of Pim-1 in cancer

Allal Ouhtit, Sukalp Muzumdar, Ishita Gupta, Somya Shanmuganathan, Yahya Tamimi

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


The Pim-1 gene encodes for a proto-oncogenic serine/threonine protein kinase and is generally involved in cytokine signaling as well as in various signaling pathways regulating cell cycle and apoptosis. Pim-1 kinase plays a role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalFrontiers in Bioscience - Elite
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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