The Role of Bupropion in the Treatment of Women with Sexual Desire Disorder: A Systematic Review and Meta-Analysis

Nur Atikah Razali, Hatta Sidi, Chia Lip Choy, Nur Aishah Che Ross, Azlin Baharudin, Srijit Das

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Although few clinical trials examined the efficacy of bupropion to treat sexual dysfunction among female patients, a comprehensive and objective synthesis of the best available evidence is still lacking. To date, to the best of our knowledge, there are no published systematic reviews or meta-analyses specifically focusing on the role of bupropion in the treatment of female sexual dys-function. The main objective of the present study was to evaluate the efficacy of bupropion in the treatment of female sexual dysfunction, and we hypothesized that bupropion is efficient in treating female patients with sexual dysfunction. This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search for published literature was performed using Ovid, Medline, Scopus, Cochrane Library, Science Di-rect, and PubMed databases. In our study, we found that bupropion was almost three-fold more fa-vorable in improving problems with sexual desire (pool estimate 2.845, 95% CI: 0.215 to 5.475, I2= 95.6%, p=0.034). A meta-regression was performed to explore heterogeneity and we found that only the dosage of bupropion was statistically significant in explaining the variance, i.e., the lower the dosage (150 mg vs. 300 mg), the better the improvement in the sexual desire of women with hypo-active sexual desire disorder (HSDD). Based on the results of this systematic review and meta-analysis, there is a potential role of bupropion as an effective treatment for women with HSDD.

Original languageEnglish
Pages (from-to)1941-1955
Number of pages15
JournalCurrent Neuropharmacology
Issue number10
Early online dateFeb 22 2022
Publication statusPublished - Oct 1 2022


  • Female sexual dysfunction
  • HSDD
  • bupropion
  • systematic review
  • treatment
  • Sexual Dysfunctions, Psychological/drug therapy
  • Bupropion/therapeutic use
  • Humans
  • Female
  • Libido
  • Treatment Outcome

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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