The effect of treatment with the medicinal plant Rhazya stricta decne on gentamicin nephrotoxicity in rats

B. H. Ali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Generation of oxygen free radicals in kidney cortex plays an important role in the pathogenesis of gentamicin (GM) nephrotoxicity, and the leaf extract of the medicinal plant Rhazya stricta has been shown to have an anti-oxidant action in rats. Therefore, in the present work we aimed at testing, in this species, the possible protective effect of R. stricta extract on GM nephrotoxicity. Crude water extract of R. Stricta leaves (0.25, 0.5 and 1 g/Kg) was given orally to rats four days before GM treatment, and thereafter, concomitantly with GM (80 mg/Kg/day) for another six days. Nephrotoxicity was evaluated histopathologically by light microscopy, and biochemically by measuring the concentrations of urea and creatinine in serum, reduced glutathione (GSH), lipid peroxidation and superoxide dismutase (SOD) activity in kidney cortex. The results suggested that the plant extract (0.25 g/Kg) was ineffective in significantly altering the indices of GM-induced nephrotoxicity. However, a dose-related amelioration in the indices of toxicity was noted when the two higher doses of the plant extract were given. The plant extract, at the three doses used, had no significant adverse effect on the body weight of treated rats or on the measured hepatic and renal functions in serum. However, the two higher doses, significantly and dose-dependently increased SOD activity and GSH concentration, and decreased that of lipid peroxides in the kidney cortex. These results suggest that R. stricta water extract may contain compounds that could potentially ameliorate GM nephrotoxicity in rats.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
Issue number5
Publication statusPublished - Jul 2002
Externally publishedYes


  • Gentamicin
  • Nephrotoxicity
  • Oxygen free radical
  • Rats
  • Rhazya stricta

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine


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