Synthesis, characterization, and pharmacological studies of ferrocene-1H-1,2,3-triazole hybrids

Ashanul Haque*, Ming Fa Hsieh, Syed Imran Hassan, Md Serajul Haque Faizi, Anannya Saha, Necmi Dege, Jahangir Ahmad Rather, Muhammad S. Khan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


A series of ferrocene-1H-1,2,3-triazole hybrids namely 1-(4-nitrophenyl)-4-ferrocenyl-1H-1,2,3-triazole (1), 1-(4,4′-dinitro-2-biphenyl)-4-ferrocenyl-1H-1,2,3-triazole (2), 1-(3-chloro-4-fluorophenyl)-4-ferrocenyl-1H-1,2,3-triazole (3), 1-(4-bromophenyl)-4-ferrocenyl-1H-1,2,3-triazole (4) and 1-(2-nitrophenyl)-4-ferrocenyl-1H-1,2,3-triazole (5) were designed and synthesized by copper-catalyzed azide alkyne cycloaddition (CuAAC) reaction. All the new hybrids were characterized by microanalyses, NMR (1H and 13C), UV–vis, IR, ESI-MS and electrochemical techniques. Crystal structure of the compound (3) was solved by single crystal X-ray diffraction method. The structural (single crystal) and spectroscopic (UV–Vis. and IR) properties of the compound 3 have been analyzed and compared by complementary quantum modeling. Hybrids 1–5 exhibited low toxicity and demonstrated neuroprotective effect.

Original languageEnglish
Pages (from-to)536-545
Number of pages10
JournalJournal of Molecular Structure
Publication statusPublished - Oct 15 2017


  • Anti-inflammatory
  • Click-chemistry
  • Copper catalyzed azide alkyne cycloaddition reaction
  • Ferrocene
  • Toxicity
  • Viability

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry


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