TY - JOUR
T1 - Physiological and Pathological Significance of Esophageal TRP Channels
T2 - Special Focus on TRPV4 in Esophageal Epithelial Cells
AU - Boudaka, Ammar
AU - Tominaga, Makoto
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (21H02667) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) to M.T.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/4/20
Y1 - 2022/4/20
N2 - Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel that is broadly expressed in different human tissues, including the digestive system, where it acts as a molecular sensor and a transducer that regulates a variety of functional activities. Despite the extensive research to determine the role of this channel in the physiology and pathophysiology of different organs, the unique morphological and functional features of TRPV4 in the esophagus remain largely unknown. Ten years ago, TRPV4 was shown to be highly expressed in esophageal epithelial cells where its activation induces Ca2+-dependent ATP release, which, in turn, mediates several functions, ranging from mechanosensation to wound healing. This review summarizes the research progress on TRPV4, and focuses on the functional expression of TRPV4 in esophageal epithelium and its possible role in different esophageal diseases that would support TRPV4 as a candidate target for future therapeutic approaches to treat patients with these conditions.
AB - Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel that is broadly expressed in different human tissues, including the digestive system, where it acts as a molecular sensor and a transducer that regulates a variety of functional activities. Despite the extensive research to determine the role of this channel in the physiology and pathophysiology of different organs, the unique morphological and functional features of TRPV4 in the esophagus remain largely unknown. Ten years ago, TRPV4 was shown to be highly expressed in esophageal epithelial cells where its activation induces Ca2+-dependent ATP release, which, in turn, mediates several functions, ranging from mechanosensation to wound healing. This review summarizes the research progress on TRPV4, and focuses on the functional expression of TRPV4 in esophageal epithelium and its possible role in different esophageal diseases that would support TRPV4 as a candidate target for future therapeutic approaches to treat patients with these conditions.
KW - ATP
KW - Ca homeostasis
KW - GERD
KW - TRPV4
KW - esophageal cancer
KW - esophageal epithelial cells
KW - esophagus
KW - ion transporters
KW - mechanosensation
KW - wound healing
KW - Epithelial Cells/metabolism
KW - Esophageal Mucosa/metabolism
KW - Humans
KW - Esophagus/metabolism
KW - TRPV Cation Channels/genetics
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UR - https://www.mendeley.com/catalogue/4c3140dd-74b9-3678-97e3-3f84bb3f18b0/
U2 - 10.3390/ijms23094550
DO - 10.3390/ijms23094550
M3 - Article
C2 - 35562940
AN - SCOPUS:85128345977
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 9
M1 - 4550
ER -
