Phosphaturic mesenchymal tumour in the temporal bone - A rare presentation

Gaurav Ashish*, John Mathew, Nihal Thomas, Nitin Kapoor, S. Elanthenral

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Tumour-induced osteomalacia (TIO) is a rare clinical entity in which secondary osteomalacia is induced by tumour-related products. There is impaired reabsorption of phosphorus in the renal tubules and hypophosphatemia as a result of over expression of FGF-23 mRNA. Treatment of choice is considered to be total or near total resection of the tumour. Methods and results: A 49-year-old man had experienced systemic bone pain and bilateral limb weakness for several months. He had refractory hypophosphatemia and marked elevation of serum FGF-23 level. Magnetic resonance imaging (MRI) of the lumbar spine showed a focal lesion in the left temporal bone which was hyper metabolic on positron emission tomography (PET) scan, leading to a diagnosis of TIO. He underwent lateral skull-base surgery after thorough evaluation of the tumour. After the en bloc resection, FGF-23 became gradually undetectable, phosphate reabsorption normalised, and all symptoms were resolved. Conclusions: We present the clinical features and treatment options for this most unusual manifestation of phosphaturic mesenchymal tumour in the temporal bone.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalEgyptian Journal of Ear, Nose, Throat and Allied Sciences
Issue number2
Publication statusPublished - 2014
Externally publishedYes


  • FGF-23
  • Lateral skull base surgery
  • TIO
  • Temporal bone

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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