Outcome of pregnancy in sickle cell anemia patients with COVID‑19 infection

Sickle cell anemia (SCA) is a multisystem disease, associated with increased risk for infection and thromboembolic disease, and pregnancy is a stressor for patients with SCA. In general, coronavirus disease 2019 (COVID‑19) infection in SCA is associated with a favorable outcome. Literature of pregnancy in SCA with COVID is scarce. We report a case series study of pregnant women with SCA, who are confirmed positive for COVID‑19 from May 2020 to March 2021. These patients showed generally mild‑to‑moderate disease and presented predominantly with fever and painful crisis. They showed a significant drop in Hb from baseline, and they received low‑molecular‑weight heparin prophylaxis (LMWH) and blood transfusion. The outcome of pregnancy is satisfactory, although the mean birth weight was significantly lower than that reported from the same SCA population.