Initial clinical and radiological features of patients with multiple sclerosis in Oman

Salma Al-Abri, Abdullah Al-Asmi*, Sachin Jose, Arunodaya R. Gujjar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background and objective: Multiple sclerosis (MS) is a lifelong demyelinating disorder with a varying disease course, resulting in different degrees of physical disability for affected patients. This study aimed to present the initial clinicoradiological features of Omani MS patients presenting to a tertiary care center in Oman. Methods: In this retrospective study, all Omani patients diagnosed with MS from January 2006 to December 2020, whose treatment and followup were conducted in our center, were included. Data was retrieved from the patients’ medical records. Disability status was assessed according to the Expanded Disability Status Scale. Results: A total of N = 155 Omani patients were diagnosed with MS of whom 68.4% were female. The mean age at diagnosis was 28.6 ± 8 years. The mean duration from symptoms to diagnosis was 1.9 years. Relapsing-remitting MS was diagnosed in 97.4% patients. Most common presenting symptoms were unifocal (84.5%), supratentorial (34.2%) and optic pathway (33.5%). At first assessment, 94.8% patients had no to mild disabilities and 3.2% had severe disabilities. During the mean follow up period of 61.2 months, the frequency of severe disabilities increased to 12.9%. Out of 155 patients, 98 (63.2%) had their initial brain magnetic resonance (MRI) report available for review, 62/98 (63%) of whom showed ≥ 20 T2-weighted (T2W) lesions. Of these lesions, 75/98 (76.5%) were periventricular, 66 (67.3%) juxtacortical, and 56 (57.1%) infratentorial. The most common initially prescribed disease modifying therapies (DMT) were interferons (104/155; 67%), followed by fingolimod (16; 10.3%), natalizumab (14; 9%) and dimethyl fumarate (4; 2.6%). Conclusions: The results of this study indicate that the demographic and clinicoradiological features of MS patients in Oman are similar to those reported elsewhere in the Arabian Gulf region.

Original languageEnglish
Article number104734
Pages (from-to)104734
JournalMultiple Sclerosis and Related Disorders
Publication statusPublished - Jul 1 2023


  • Disability evaluation
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Nervous system diseases
  • Oman
  • Signs and symptoms
  • Humans
  • Male
  • Multiple Sclerosis/diagnostic imaging
  • Multiple Sclerosis, Relapsing-Remitting/drug therapy
  • Young Adult
  • Oman/epidemiology
  • Female
  • Adult
  • Immunosuppressive Agents/therapeutic use
  • Retrospective Studies
  • Immunologic Factors/therapeutic use

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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