Autism and Gut–Brain Axis: Role of Probiotics

Saravana Babu Chidambaram*, Sunanda Tuladhar, Abid Bhat, Arehally Marappa Mahalakshmi, Bipul Ray, Musthafa Mohamed Essa, Muhammed Bishir, Srinivasa Rao Bolla, Nandakumar Dalavaikodihalli Nanjaiah, Gilles J. Guillemin, M. Walid Qoronfleh

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Citations (Scopus)


Characterized by a wide range of behavioural, social and language problems, autism is a complex developmental disability that affects an individual’s capacity to communicate and interact with others. Although the real causes that lead to the development of autism are still unclear, the gastrointestinal tract has been found to play a major role in the development of autism. Alterations in macrobiotic compositions have been reported in autistic children. Irregularities in carbohydrate digestion and absorption could also explain some of the gastrointestinal problems reported in autistic patients, although their role in the neurological and behavioural problems remains uncertain. A relationship between improved gut health and decrease of symptoms in autism has been reported as well. Studies done to evaluate the gluten-free diets, casein-free diets, pre- and probiotic and multivitamin supplementation have shown promising results. Probiotics have been thought to alleviate the progression of autism and reduce cognitive and behavioural deficits.

Original languageEnglish
Title of host publicationAdvances in Neurobiology
Number of pages14
Publication statusPublished - 2020

Publication series

NameAdvances in neurobiology
PublisherSpringer Publishing Company
ISSN (Print)2190-5215


  • ASD
  • Autism
  • Barrier pathway
  • Cognitive and behavioural deficits
  • GI dysfunction
  • Gut–brain axis
  • Microbiome
  • Probiotics
  • Autistic Disorder/diet therapy
  • Probiotics/therapeutic use
  • Humans
  • Brain/physiopathology
  • Dietary Carbohydrates/metabolism
  • Gastrointestinal Tract/physiopathology

ASJC Scopus subject areas

  • Biochemistry
  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience


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