Antioxidative capacity of hydrochlorothiazide and atenolol in long-term hypertension therapy

Devarajan Sankar*, Amanat Ali, Saraswathi Raman, Yoshmari Uehara, Sambandam Ganapathy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objective: To study the antioxidative prospective of diuretics (hydrochlorothiazide) or β-blockers (atenolol) in long-term hypertension therapy. Methods: Enzymatic and non-enzymatic antioxidants , and lipid peroxidation in blood was measured in hypertensive patients on long-term medication with either diuretics or β-blockers , and they were compared with agematched untreated hypertensive patients , and normal subjects. Results: Plasma levels of lipid peroxidation as thiobarbituric acid reactive substances (TBARS) in untreated hypertensive patients were significantly (P < 0. 05) higher while the levels of enzymatic and non-enzymatic antioxidants were significantly lower (P < 0. 05) as compared to hypertensive patients with medication,and normal subjects. Between the two drug treated hypertensive groups, although no significant (P < 0.05) differences were observed in blood pressure , a significant improvement in the status of enzymatic ( superoxide dismutase , catalase and glutathione peroxidase) and non-enzymatic (vitamin C , vitamin E , β-carotene and reduced glutathione) antioxidants were observed in atenolol treated group compared to untreated hypertensive patients , and patients treated with hydrochlorothiazide. Conclusion: The results of the present study suggest that atenolol has better antioxidative capacity by protecting the enzymatic and non-enzymatic antioxidants when compared with hydrochlorothiazide therapy.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalJournal of Chinese Clinical Medicine
Issue number3
Publication statusPublished - Mar 2010


  • Antioxidants
  • Atenolol
  • Hydrochlorothiazide
  • Lipid peroxidation
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)


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